New neurons are generated throughout life in distinct regions of the mammalian brain due to the proliferation and differentiation of neural stem cells (NSCs). Ubiquitin, a post-translational modification of cellular proteins, is an important factor in regulating neurogenesis. Deubiquitination is a biochemical process that mediates the removal of ubiquitin moieties from ubiquitin-conjugated substrates. Recent studies have provided growing evidence that deubiquitylases (DUBs) which reverse ubiquitylation process play critical roles in NSCs maintenance, differentiation and maturation. This review mainly focused on the relationship of DUBs and NSCs, and further summarized recent advances in our understanding of DUBs on regulating NSCs biological behaviors.

中文翻译：

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去泛素酶对神经干细胞生物学行为的影响

由于神经干细胞 (NSC) 的增殖和分化，哺乳动物大脑的不同区域在整个生命过程中都会产生新的神经元。泛素是一种细胞蛋白的翻译后修饰，是调节神经发生的重要因素。去泛素化是介导从泛素缀合的底物中去除泛素部分的生化过程。最近的研究提供了越来越多的证据表明，逆转泛素化过程的去泛素化酶 (DUB) 在 NSC 的维持、分化和成熟中起关键作用。本综述主要关注 DUBs 和 NSCs 的关系，并进一步总结了我们对 DUBs 在调节 NSCs 生物学行为方面的认识的最新进展。