This study assesses the effect of extent of resection (EOR) on the longer-term survival and early mortality of elderly patients (≥ 75 years old) with glioblastoma. We used the Surveillance, Epidemiology, and End Results (SEER) database and data from our center to evaluate the effect of EOR on the long-term survival and early mortality of patients with glioblastoma. We included 50 elderly patients (≥ 75 years old) with glioblastoma visiting our hospital. The median overall survival of the patients who underwent a gross total resection, a subtotal resection, and a partial resection were 278, 200, and 83 days, respectively. The multivariate analysis showed that gross total resection (HR: 0.100; 95% CI: 0.015–0.671, p < 0.001) and subtotal reresection (HR: 0.134, 95% CI: 0.022–0.831, p < 0.001) were independent predictors of favorable prognosis when compared with partial resection. The data extracted from the SEER database also indicated that EOR was an independent predictor of OS, CCS, and early mortality. The stratification analysis revealed that gross total resection was the best protective factor of OS, early mortality, and CCS. Radical resection may improve the OS and CCS of glioblastoma patients aged ≥ 75 years and decrease early mortality.

本研究评估了切除范围 (EOR) 对老年胶质母细胞瘤患者（≥ 75 岁）的长期生存率和早期死亡率的影响。我们使用监测、流行病学和最终结果 (SEER) 数据库和我们中心的数据来评估 EOR 对胶质母细胞瘤患者长期生存和早期死亡率的影响。我们纳入了 50 名到我院就诊的胶质母细胞瘤老年患者（≥ 75 岁）。接受大体全切除术、次全切除术和部分切除术的患者的中位总生存期分别为 278、200 和 83 天。多变量分析显示，总切除（HR：0.100；95% CI：0.015-0.671，p  < 0.001）和次全切除（HR：0.134，95% CI：0.022-0.831，p < 0.001) 是与部分切除相比预后良好的独立预测因子。从 SEER 数据库中提取的数据还表明，EOR 是 OS、CCS 和早期死亡率的独立预测因子。分层分析显示，总切除是 OS、早期死亡率和 CCS 的最佳保护因素。根治性切除可改善≥75岁胶质母细胞瘤患者的OS和CCS，降低早期死亡率。