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Acute-stress induced change in salience network coupling prospectively predicts post-trauma symptom-development
medRxiv - Psychiatry and Clinical Psychology Pub Date : 2021-12-10 , DOI: 10.1101/2021.07.03.21259969
Wei Zhang , Reinoud Kaldewaij , Mahur M. Hashemi , Saskia B.J. Koch , Annika Smit , Vanessa van Ast , Christian F. Beckmann , Floris Klumpers , Karin Roelofs

Substantial individual differences exist in how acute stress affects large-scale neurocognitive networks, including Salience (SN), Default Mode (DMN) and Central Executive Networks (CEN). Changes in the connectivity strength of these network upon acute stress may predict vulnerability to long-term stress effects, which can only be tested in prospective longitudinal studies. Using such longitudinal design, we investigated whether the magnitude of acute-stress induced functional connectivity changes (delta-FC) predicts the development of posttraumatic stress disorder (PTSD) symptoms in a relatively resilient group of young police students that are known to be at high risk for trauma-exposure.

中文翻译:

急性压力引起的显着性网络耦合的变化前瞻性地预测了创伤后症状的发展

急性压力如何影响大规模神经认知网络,包括显着性 (SN)、默认模式 (DMN) 和中央执行网络 (CEN),存在显着的个体差异。这些网络在急性压力下连接强度的变化可以预测对长期压力影响的脆弱性,这只能在前瞻性纵向研究中进行测试。使用这种纵向设计,我们调查了急性压力引起的功能连接变化 (delta-FC) 的幅度是否可以预测相对有弹性的年轻警察学生群体的创伤后应激障碍 (PTSD) 症状的发展,这些年轻警察学生已知处于高外伤暴露的风险。
更新日期:2021-12-13
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