Purpose of Review

This article is a systematic review of data from 2018 to 2020 regarding information from publications on epidemiologic, diagnostic, and therapeutic advancements in human immunodeficiency virus–associated peripheral neuropathy.

Recent Findings

The epidemiology/pathology of HIV neuropathy is discussed. Diagnostics includes skin wrinkling-eutectic mixture of local anesthetic test and neurologic examinations. Therapeutic interventions include pharmacologic and nonpharmacologic management as well as self-management strategies.

Summary

Peripheral neuropathy continues to affect the lives of persons living with HIV. First-line treatment with pregabalin or gabapentin for HIV neuropathic pain has limited data on adequate response. Exercise and self-management strategies may provide benefit in pain reduction. Continuing research on risk factors and biomarkers for HIV-related peripheral neuropathy will be critical for future diagnostic and therapeutic agents.

中文翻译：

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HIV 神经病变——疼痛的机制、诊断和治疗综述

审查目的

本文是对 2018 年至 2020 年有关人类免疫缺陷病毒相关周围神经病变流行病学、诊断和治疗进展出版物信息的数据的系统回顾。

最近的发现

讨论了 HIV 神经病变的流行病学/病理学。诊断包括局部麻醉试验和神经系统检查的皮肤皱纹-共晶混合物。治疗干预包括药物和非药物管理以及自我管理策略。

概括

周围神经病变继续影响艾滋病毒感染者的生活。普瑞巴林或加巴喷丁一线治疗 HIV 神经性疼痛的充分反应数据有限。锻炼和自我管理策略可能有助于减轻疼痛。继续研究 HIV 相关周围神经病变的风险因素和生物标志物对于未来的诊断和治疗药物至关重要。