The study aimed to evaluate the parameters of lipid peroxidation and antioxidant protection, biochemical parameters, and cortisol and adrenaline content in the blood of students depending on the effect of exam stress. A total of 135 healthy students (72 female (53.3%) and 63 male (46.7%)) aged from 19 to 21 years (mean age 20.16 ± 0.42 years) of the experimental group underwent detailed medical screening and examination before the inclusion in the study. The control group consisted of 30 healthy students (17 female (56.7%) and 13 male (43.3%)) of corresponding age (mean age 20.23 ± 0.54 years), whose medical examination was performed during breaks in the absence of any stress factors. The blood parameters of the experimental group were investigated 1 h before, 1 h after, and 24 h after the exam. The cortisol content in the blood of experimental group students significantly increased 1.37 times (p < 0.05) an hour before the exam and 1.32 times (p < 0.05) an hour after; adrenalin content in blood increased 1.76 times (p < 0.05) and 1.49 times (p < 0.05), respectively. Compared to the control group, intensification of lipid peroxidation processes with a 1.51-fold (p < 0.05) increase in erythrocyte malonic aldehyde content in blood 1 h before and 1.42-fold (p < 0.05) increase an hour after the exam was observed in students due to the effect of exam stress.. Changes in hormonal homeostasis, activation of lipoperoxidation processes with the development of oxidative stress, and the disintegration of antioxidant protection factors are typical for academic stress in students.

该研究旨在根据考试压力的影响，评估学生血液中的脂质过氧化和抗氧化保护参数、生化参数以及皮质醇和肾上腺素含量。实验组共有135名年龄在19至21岁（平均年龄20.16±0.42岁）的健康学生（72名女性（53.3%）和63名男性（46.7%））在纳入研究之前接受了详细的医学筛查和检查。学习。对照组由30名相应年龄（平均年龄20.23±0.54岁）的健康学生组成（17名女性（56.7％）和13名男性（43.3％）），在没有任何压力因素的休息期间进行体检。分别于检查前1小时、检查后1小时、检查后24小时测定实验组的血液参数。实验组学生血液中的皮质醇含量在考试前一小时显着增加1.37倍（p < 0.05），在考试后一小时显着增加1.32倍（p < 0.05）；血液中肾上腺素含量分别增加1.76倍（p < 0.05）和1.49倍（p < 0.05）。与对照组相比，脂质过氧化过程加剧，检查前 1 小时血液中红细胞丙二醛含量增加 1.51 倍（p < 0.05），检查后 1 小时增加 1.42 倍（p < 0.05）。荷尔蒙稳态的变化、氧化应激发展引起的脂过氧化过程的激活以及抗氧化保护因子的瓦解是学生学业压力的典型表现。