ABSTRACT

Candida albicans, which can cause superficial and life-threatening systemic infections, is the most common opportunistic fungal pathogen in the human microbiome. The two-component system is one of the most important C. albicans signal transduction pathways, regulating the response to oxidative and osmotic stresses, adhesion, morphogenesis, cell wall synthesis, virulence, drug resistance, and the host–pathogen interactions. Notably, some components of this signaling pathway have not been found in the human genome, indicating that the two-component system of C. albicans can be a potential target for new antifungal agents. Here, we summarize the composition, signal transduction, and regulation of the two-component system of C. albicans to emphasize its essential roles in the pathogenesis of C. albicans and the new therapeutic target for antifungal drugs.

摘要

白色念珠菌可引起浅表和危及生命的全身感染，是人类微生物组中最常见的机会性真菌病原体。双组分系统是白色念珠菌最重要的信号转导途径之一，调节对氧化和渗透应激、粘附、形态发生、细胞壁合成、毒力、耐药性和宿主-病原体相互作用的反应。值得注意的是，该信号通路的某些成分尚未在人类基因组中发现，这表明白色念珠菌的双成分系统可以成为新型抗真菌药物的潜在靶标。在这里，我们总结了白色念珠菌双组分系统的组成、信号转导和调控，强调其在白色念珠菌发病机制中的重要作用以及抗真菌药物的新治疗靶点。