Abstract

Background

Inflammation is crucial in the pathogenesis of lower urinary tract symptoms (LUTS) in men. Diet modulates inflammation. Therefore, diet could be a modifiable factor in male LUTS prevention and treatment. We aimed to investigate the association between dietary inflammatory potential and male LUTS.

Methods

We used two cycles of National Health and Nutrition Examination Survey (NHANES) with self-report LUTS data. We calculated the dietary inflammatory index (DII) based on a 24 h diet recall and evaluated male LUTS. Clinical LUTS was defined as two or more coexisting symptoms. We used univariate and multivariate logistic regression models, the smooth curve fitting to analyze the relationship between clinical LUTS and the DII score. Subgroup analyses were conducted.

Results

We observed a positive non-linear relationship between clinical LUTS and DII. We found that when DII was higher than the inflection point 2.39, a 1-unit increase in DII was associated with 26.1% higher adjusted odds of clinical LUTS. Subgroup analyses showed that the DII score was only positively correlated with clinical LUTS risk in non-drinkers, smokers, and non-obese people (DII >2.39).

Conclusions

Inflammation might be the key mechanism bridging dietary consumption to male LUTS. Excessive pro-inflammatory food intake (DII >2.39) warrants special vigilance, especially for non-drinkers, smokers, and non-obese men.

中文翻译：

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美国男性饮食的炎症潜能与下尿路症状的关联

摘要

背景

炎症在男性下尿路症状 (LUTS) 的发病机制中至关重要。饮食调节炎症。因此，饮食可能是男性 LUTS 预防和治疗的一个可改变因素。我们旨在调查饮食炎症潜能与男性 LUTS 之间的关联。

方法

我们使用了两个周期的国家健康和营养检查调查 (NHANES) 以及自我报告的 LUTS 数据。我们根据 24 小时饮食回忆计算了饮食炎症指数 (DII)，并评估了男性 LUTS。临床 LUTS 被定义为两种或两种以上并存的症状。我们使用单变量和多变量逻辑回归模型，平滑曲线拟合来分析临床LUTS与DII评分之间的关​​系。进行了亚组分析。

结果

我们观察到临床 LUTS 和 DII 之间存在正的非线性关系。我们发现，当 DII 高于拐点 2.39 时，DII 增加 1 个单位与临床 LUTS 调整后的几率增加 26.1% 相关。亚组分析显示，DII 评分仅与非饮酒者、吸烟者和非肥胖者的临床 LUTS 风险呈正相关（DII >2.39）。

结论

炎症可能是将饮食消费与男性 LUTS 联系起来的关键机制。过量的促炎食物摄入（DII >2.39）需要特别警惕，尤其是对于不饮酒者、吸烟者和非肥胖男性。