Recent Advances in Theoretical Studies on Transition-Metal-Catalyzed Carbene Transformations,Accounts of Chemical Research

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Recent Advances in Theoretical Studies on Transition-Metal-Catalyzed Carbene Transformations
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2021-07-07 , DOI: 10.1021/acs.accounts.1c00075
Xiaotian Qi _{1,

2} , Yu Lan _{1,

3}

Affiliation

Metal carbene plays a vital role in modern organic synthesis. The neutral divalent carbon of metal carbene renders it an active intermediate throughout a range of reactions. In experiments, diverse metal carbene-related transformation reactions have been established, including transition-metal-catalyzed cross-coupling reactions using N-heterocyclic carbenes as ligands, metal carbene insertion into σ bonds, cyclopropanations, ylide formation, and so forth. The remarkable progress achieved in synthetic chemistry, in turn, has increased the demand for mechanistic studies of carbene chemistry. A thorough understanding of reaction mechanisms can extend the application scope of metal carbene compounds and inspire the rational design of new carbene transformation reactions.

中文翻译：

过渡金属催化的卡宾转化理论研究新进展

金属卡宾在现代有机合成中起着至关重要的作用。金属卡宾的中性二价碳使其成为一系列反应中的活性中间体。在实验中，已经建立了多种与金属卡宾相关的转化反应，包括使用N-杂环卡宾作为配体的过渡金属催化的交叉偶联反应、金属卡宾插入 σ 键、环丙烷化、叶立德形成等。合成化学取得的显着进展反过来又增加了对卡宾化学机理研究的需求。对反应机理的透彻理解可以扩展金属卡宾化合物的应用范围，并激发新的卡宾转化反应的合理设计。

更新日期：2021-07-20

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