Residual native kidney function confers health benefits in patients on dialysis. It can facilitate control of extracellular volume and inorganic ion concentrations. Residual kidney function can also limit the accumulation of uremic solutes. This study assessed whether lower plasma concentrations of uremic solutes were associated with residual kidney function in pediatric patients on peritoneal dialysis.

Samples were analyzed from 29 pediatric patients on peritoneal dialysis, including 13 without residual kidney function and ten with residual kidney function. Metabolomic analysis by untargeted mass spectrometry compared plasma solute levels in patients with and without residual kidney function. Dialytic and residual clearances of selected solutes were also measured by assays using chemical standards.

Metabolomic analysis showed that plasma levels of 256 uremic solutes in patients with residual kidney function averaged 64% (interquartile range, 51%–81%) of the values in patients without residual kidney function who had similar total Kt/V_urea. The plasma levels were significantly lower for 59 of the 256 solutes in the patients with residual kidney function and significantly higher for none. Assays using chemical standards showed that residual kidney function provides a higher portion of the total clearance for nonurea solutes than it does for urea.

Concentrations of many uremic solutes are lower in patients on peritoneal dialysis with residual kidney function than in those without residual kidney function receiving similar treatment as assessed by Kt/V_urea.

残留的天然肾功能对透析患者的健康有益。它可以促进细胞外体积和无机离子浓度的控制。残余肾功能也可以限制尿毒症溶质的积累。本研究评估了较低的尿毒症溶质血浆浓度是否与接受腹膜透析的儿科患者的残余肾功能相关。

分析了 29 名接受腹膜透析的儿科患者的样本，其中 13 名没有残余肾功能，10 名有残余肾功能。通过非靶向质谱法进行的代谢组学分析比较了有和没有残余肾功能患者的血浆溶质水平。所选溶质的透析和残留清除率也通过使用化学标准的测定法进行测量。

代谢组学分析显示，有残余肾功能患者的 256 种尿毒症溶质的血浆水平平均为无残余肾功能且具有相似总 Kt/V_尿素患者值的 64%（四分位间距，51%–81%） 。在有残余肾功能的患者中，256 种溶质中有 59 种的血浆水平显着降低，而没有显着升高。使用化学标准的测定表明，残余肾功能对非尿素溶质的总清除率比对尿素的清除率更高。

许多尿毒症溶质的浓度在有残余肾功能的腹膜透析患者中​​低于接受类似治疗的无残余肾功能的患者，如 Kt/V_尿素所评估。