Advances in our understanding of uremic retention solutes, and improvements in hemodialysis membranes and other techniques designed to remove uremic retention solutes, offer opportunities to readdress the definition and classification of uremic toxins. A consensus conference was held to develop recommendations for an updated definition and classification scheme on the basis of a holistic approach that incorporates physicochemical characteristics and dialytic removal patterns of uremic retention solutes and their linkage to clinical symptoms and outcomes. The major focus is on the removal of uremic retention solutes by hemodialysis. The identification of representative biomarkers for different classes of uremic retention solutes and their correlation to clinical symptoms and outcomes may facilitate personalized and targeted dialysis prescriptions to improve quality of life, morbidity, and mortality. Recommendations for areas of future research were also formulated, aimed at improving understanding of uremic solutes and improving outcomes in patients with CKD.

我们对尿毒症潴留溶质理解的进步，以及血液透析膜和其他旨在去除尿毒症潴留溶质的技术的改进，为重新解决尿毒症毒素的定义和分类提供了机会。召开了一次共识会议，以综合考虑尿毒症潴留溶质的理化特征和透析清除模式及其与临床症状和结果的联系的整体方法为基础，制定更新的定义和分类方案的建议。主要焦点是通过血液透析去除尿毒症潴留溶质。鉴定不同类别尿毒症潴留溶质的代表性生物标志物及其与临床症状和结果的相关性可能有助于个性化和有针对性的透析处方，以改善生活质量、发病率和死亡率。还制定了未来研究领域的建议，旨在提高对尿毒症溶质的了解并改善 CKD 患者的预后。