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Antiviral drugs arbidol and interferon alpha-1b contribute to reducing the severity of COVID-19 patients: a retrospective cohort study
Virology Journal ( IF 4.0 ) Pub Date : 2021-07-08 , DOI: 10.1186/s12985-021-01617-w Peng Yin 1 , Juan Meng 2 , Jincheng Chen 3 , Junxiao Gao 1 , Dongqi Wang 1 , Shuyan Liu 2 , Qinglong Guo 2 , Muchun Zhu 1 , Gengwei Zhang 2 , Yingxia Liu 2, 3 , Ye Li 1 , Guoliang Zhang 2
Virology Journal ( IF 4.0 ) Pub Date : 2021-07-08 , DOI: 10.1186/s12985-021-01617-w Peng Yin 1 , Juan Meng 2 , Jincheng Chen 3 , Junxiao Gao 1 , Dongqi Wang 1 , Shuyan Liu 2 , Qinglong Guo 2 , Muchun Zhu 1 , Gengwei Zhang 2 , Yingxia Liu 2, 3 , Ye Li 1 , Guoliang Zhang 2
Affiliation
The aim of this study was to evaluate the role of antiviral drugs in reducing the risk of developing severe illness in patients with moderate COVID-19 pneumonia. This retrospective cohort study included 403 adult patients with moderate COVID-19 pneumonia who were admitted to Shenzhen Third People’s Hospital, China. The antiviral drugs arbidol, interferon alpha-1b, lopinavir–ritonavir and ribavirin were distributed to the patients for treatment. The primary endpoint of this study was the time to develop severe illness. Of the 462 patients admitted, 403 had moderate COVID-19 symptoms at hospital admission and were included in this study. 90 of the 403 (22.3%) patients progressed to severe illness. The use of arbidol was associated with a lower severity rate 3.5% compared to control group 30.5%, p-value < 0.0001; the adjusted hazard ratio was 0.28 (95% CI: 0.084–0.90, p = 0.033). The use of interferon alpha-1b was associated with a lower severity rate 15.5% compared to control group 29.3%, with p-value < 0.0001; the adjusted hazard ratio was 0.30 (95% CI: 0.15–0.58, p = 0.0005). The use of lopinavir–itonavir and ribavirin did not show significant differences in adjusted regression models. Early use of arbidol within 7 days of symptom onset was significantly associated with a reduced recovery time of − 5.2 days (IQR − 3.0 to − 7.5, p = 4e−06) compared with the control group. Treatment with arbidol and interferon alpha-1b contributes to reducing the severity of illness in patients with moderate COVID-19 pneumonia. Early use of arbidol may reduce patients’ recovery time.
更新日期：2021-07-08
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