Abstract

Background and aim

To investigate the influence of common factors on serum immunoglobulin M (IgM) concentrations in adults, and clinical associations with high and low values.

Methods

We measured serum IgM levels using immunonephelometry in a random sample of 1510 individuals (aged 18–91 years, 44.7% male). We obtained data defining metabolic syndrome from all participants, defined atopy by skin prick tests to aeroallergens, and assessed lifestyle factors by questionnaire.

Results

Women showed higher IgM concentrations than men; 95 (6.3%, mostly male) individuals showed low (<0.40 g/L) IgM values, and 64 (4.2%, mostly female) showed high (>2.30 g/L) IgM values. Individuals with abnormal IgM concentrations had no history of opportunistic infections nor a different atopy prevalence. Serum IgM concentrations decreased with age, and obesity was negatively associated with IgM concentrations. Alcohol consumption, smoking, physical activity, and metabolic syndrome had no significant influence in the multivariate analyses.

Conclusions

Many adults in the general population show abnormally high or low IgM concentrations with no evidence of immunodeficiency-associated diseases. Sex and age should be considered when defining reference IgM concentrations.

中文翻译：

---

与血清 IgM 浓度相关的因素：一般成人人群研究

摘要

背景和目标

调查常见因素对成人血清免疫球蛋白 M (IgM) 浓度的影响，以及与高值和低值的临床关联。

方法

我们使用免疫比浊法测量了 1510 名个体（年龄 18-91 岁，44.7% 男性）的随机样本中的血清 IgM 水平。我们从所有参与者那里获得了定义代谢综合征的数据，通过对气源性过敏原的皮肤点刺试验定义了特应性，并通过问卷评估了生活方式因素。

结果

女性的 IgM 浓度高于男性；95 人（6.3%，主要是男性）的 IgM 值较低（<0.40 g/L），64 人（4.2%，主要是女性）的 IgM 值较高（>2.30 g/L）。IgM 浓度异常的个体没有机会性感染史，也没有不同的特应性患病率。血清 IgM 浓度随年龄增长而降低，肥胖与 IgM 浓度呈负相关。饮酒、吸烟、体力活动和代谢综合征在多变量分析中没有显着影响。

结论

一般人群中的许多成年人表现出异常高或低的 IgM 浓度，而没有免疫缺陷相关疾病的证据。定义参考 IgM 浓度时应考虑性别和年龄。