Journal of Nanoparticle Research ( IF 2.1 ) Pub Date : 2021-07-08 , DOI: 10.1007/s11051-021-05276-4 Vinitha Rani 1 , Jayachandran Venkatesan 1 , Ashwini Prabhu 1
|
Angiogenesis is considered one of the hallmarks in tumor biology which contributes to metastasis and tumor progression by promoting the growth and development of blood vessels in order to supply nutrients and oxygen to the growing cancer cells. Numerous attempts have been made to target the mechanism of angiogenesis, out of which the most approachable method is the administration of angiogenesis inhibitors to target the growth of new blood vessels, which seems to be a powerful tool in targeted drug delivery when incorporated into nanocarriers and directed towards the tumor site. The main objective of this review is to focus on the importance of gold nanocrystals as an emerging tool in targeting tumor angiogenesis, and thereby facilitate tumor diagnosis and therapy. This review deals with the remarkable physicochemical and biological features of gold nanocrystals that make them ideal drug delivery systems. It gives an overview of the preclinical and clinical studies carried out using gold nanocrystals and also describes the recent advances in the applications of gold nanocrystals in tumor diagnosis, imaging, photodynamic therapy, and drug delivery, along with their limitations. Gold nanocrystals have proven to show promising effects in tumor-specific delivery of the drugs and are beneficial in reducing the undue effects on the surrounding normal cells and also in enhancing the intratumoral drug accumulation. Hence, they could be exploited as potential antiangiogenic agents and as targeted cancer therapeutics.
Graphical abstract
中文翻译：
金纳米晶体作为肿瘤血管生成的潜在抑制剂：对诊断和药物递送的影响
血管生成被认为是肿瘤生物学中的标志之一，它通过促进血管的生长和发育从而为生长中的癌细胞提供营养和氧气来促进转移和肿瘤进展。已经进行了许多针对血管生成机制的尝试，其中最可行的方法是施用血管生成抑制剂以靶向新血管的生长，当掺入纳米载体中时，这似乎是靶向药物递送的有力工具和指向肿瘤部位。本综述的主要目的是关注金纳米晶体作为靶向肿瘤血管生成的新兴工具的重要性，从而促进肿瘤诊断和治疗。这篇综述讨论了金纳米晶体显着的物理化学和生物学特性，这些特性使它们成为理想的药物输送系统。它概述了使用金纳米晶体进行的临床前和临床研究，还描述了金纳米晶体在肿瘤诊断、成像、光动力治疗和药物输送中的应用的最新进展及其局限性。金纳米晶体已被证明在药物的肿瘤特异性递送方面显示出有希望的效果，并且有利于减少对周围正常细胞的过度影响，并有助于增强肿瘤内药物的积累。因此，它们可以用作潜在的抗血管生成剂和靶向癌症治疗剂。它概述了使用金纳米晶体进行的临床前和临床研究，还描述了金纳米晶体在肿瘤诊断、成像、光动力治疗和药物输送中的应用的最新进展及其局限性。金纳米晶体已被证明在药物的肿瘤特异性递送方面显示出有希望的效果，并且有利于减少对周围正常细胞的过度影响，并有助于增强肿瘤内药物的积累。因此，它们可以用作潜在的抗血管生成剂和靶向癌症治疗剂。它概述了使用金纳米晶体进行的临床前和临床研究，还描述了金纳米晶体在肿瘤诊断、成像、光动力治疗和药物输送中的应用的最新进展及其局限性。金纳米晶体已被证明在药物的肿瘤特异性递送方面显示出有希望的效果，并且有利于减少对周围正常细胞的过度影响，并有助于增强肿瘤内药物的积累。因此，它们可以用作潜在的抗血管生成剂和靶向癌症治疗剂。金纳米晶体已被证明在药物的肿瘤特异性递送方面显示出有希望的效果，并且有利于减少对周围正常细胞的过度影响，并有助于增强肿瘤内药物的积累。因此，它们可以用作潜在的抗血管生成剂和靶向癌症治疗剂。金纳米晶体已被证明在药物的肿瘤特异性递送方面显示出有希望的效果，并且有利于减少对周围正常细胞的过度影响，并有助于增强肿瘤内药物的积累。因此，它们可以用作潜在的抗血管生成剂和靶向癌症治疗剂。
京公网安备 11010802027423号