Background. The biological link between severe periodontitis and cardiovascular disease is well established. Both complex inflammatory diseases are influenced by genetic background. Therefore, the impact of genetic variations of receptors of the innate immune system—(Toll-like receptors (TLRs)) TLR2, TLR4, cluster of differentiation 14 (CD14), and the transcription factor nuclear factor-κΒ (NF-κB)—was investigated. Materials and Methods. In this study (ClinicalTrials.gov identifier: NCT01045070), 1002 cardiovascular (CV) patients were included. In a 3-year follow-up period, new vascular events were assessed. SNPs in CD14 (rs2569190), NF-κΒ (rs28362491), TLR2 (rs5743708), and TLR4 (rs4986790) were genotyped. The impact of these genetic variants on severe periodontitis as well as on CV outcome was assessed. Results. All investigated genetic variants were not associated with preexisting CV events or severe periodontitis in CV patients. In Kaplan-Meier survival analyses, the CT genotype of CD14 single-nucleotide polymorphism (SNP) rs2569190 was shown to be an independent predictor for combined CV endpoint (log rank: ; cox regression; hazard ratio: 1.572; ) as well as cardiovascular death (log rank: ; cox regression; hazard ratio: 1.585; ) after three years of follow-up. Conclusions. SNPs in CD14, NF-κΒ, TLR2, and TLR4 are no risk modulators for preexisting CV events or severe periodontitis in CV patients. The CT genotype of CD14 SNP rs2569190 provides prognostic value for further CV events within 3 years of follow-up.

中文翻译：

---

CD14基因多态性与心血管疾病患者不良结局相关

背景。严重牙周炎和心血管疾病之间的生物学联系已经确立。这两种复杂的炎症性疾病都受遗传背景的影响。因此，先天免疫系统受体（Toll 样受体 (TLRs)）TLR2、TLR4、分化簇 14 (CD14) 和转录因子核因子-κB (NF-κB )的遗传变异的影响——被调查。材料和方法。在这项研究（ClinicalTrials.gov 标识符：NCT01045070）中，包括了 1002 名心血管（CV）患者。在 3 年的随访期间，评估了新的血管事件。CD14 (rs2569190)、NF-κΒ 中的SNP(rs28362491)、TLR2 (rs5743708) 和 TLR4 (rs4986790) 进行基因分型。评估了这些遗传变异对严重牙周炎以及 CV 结果的影响。结果。所有研究的遗传变异均与 CV 患者先前存在的 CV 事件或严重牙周炎无关。在 Kaplan-Meier 生存分析中，CD14 单核苷酸多态性 (SNP) rs2569190 的 CT 基因型被证明是联合 CV 终点的独立预测因子（对数秩：; 考克斯回归；风险比：1.572；）以及心血管死亡（对数秩：; 考克斯回归；风险比：1.585；)经过三年的随访。结论。CD14、NF-κB、TLR2 和 TLR4 中的 SNP不是CV 患者中先前存在的 CV 事件或严重牙周炎的风险调节剂。CD14 SNP rs2569190 的 CT 基因型为随访 3 年内进一步的 CV 事件提供了预后价值。