Cell-free fetal DNA (cffDNA) shed from the placenta can be detected in maternal blood and increases incrementally during gestation. Concentrations are further elevated with pregnancy complications. Specific activators of cffDNA release in such complications have not been identified. Here, we use trophoblast cells from early and term placenta to examine cffDNA release following apoptosis, infection, and sterile inflammatory stress.

中文翻译：

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人滋养层细胞凋亡和无菌炎症后无细胞胎儿 DNA 释放增加

从胎盘脱落的游离胎儿 DNA (cffDNA) 可以在母体血液中检测到，并且在妊娠期间逐渐增加。随着妊娠并发症，浓度进一步升高。尚未确定此类并发症中 cffDNA 释放的特定激活剂。在这里，我们使用来自早期和足月胎盘的滋养层细胞来检查细胞凋亡、感染和无菌炎症应激后 cffDNA 的释放。