HOCl-Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors,Advanced Science

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HOCl-Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors
Advanced Science ( IF 14.3 ) Pub Date : 2021-07-08 , DOI: 10.1002/advs.202100074
Dongya Liu ₁ , Lingyan Liu ₁ , Feiyang Liu ₁ , Mengfan Zhang ₁ , Peng Wei ₂ , Tao Yi _{1,

2}

Affiliation

Tumor microenvironment-responsive nanodrugs offer promising opportunities for imaging-guided precision therapy with reduced side effects. Considering that the antitumor effect is closely related to the size of the nanodrugs, it is particularly important to develop a therapeutic system with size adjustability in the tumor microenvironment, which is still a great challenge in the field of nanotheranostics. Herein, a reactive oxygen species (ROS)-activated aggregation strategy is reported for imaging-guided precision therapy of tumors. The ROS-activated nanoplatform is constructed based on gold nanoparticles (AuNPs) coated with an HOCl probe on its surface (namely, Au–MB–PEG NPs). The Au–MB–PEG NPs show high sensitivity toward HOCl, resulting in the modulation of surface charge and rapid aggregation of AuNPs, and simultaneous release of methylene blue as a photosensitizer for photodynamic therapy (PDT). In the tumor environment, the aggregated AuNPs ensure higher tumor accumulation and retention. Furthermore, the redshift of the absorption of aggregated AuNPs leads to activated photoacoustic imaging signals and photothermal therapy (PTT) under near-infrared irradiation. Au–MB–PEG NPs thus efficiently inhibit the tumor growth through combined PTT–PDT therapy. This work contributes to the design of stimuli-induced size-aggregation nanodrugs, thereby attaining advanced performance in cancer diagnosis and treatment.

中文翻译：

HOCl 激活的金纳米颗粒聚集体用于肿瘤多模式治疗

肿瘤微环境响应性纳米药物为成像引导的精准治疗提供了有希望的机会，并减少了副作用。考虑到抗肿瘤作用与纳米药物的尺寸密切相关，开发一种在肿瘤微环境中尺寸可调的治疗系统显得尤为重要，这仍然是纳米治疗领域的一个巨大挑战。在此，报道了一种活性氧（ROS）激活的聚集策略，用于成像引导的肿瘤精准治疗。ROS激活的纳米平台是基于表面涂有HOCl探针的金纳米粒子（AuNPs）（即Au-MB-PEG NPs）构建的。Au-MB-PEG NPs 对 HOCl 表现出高敏感性，导致表面电荷的调节和 AuNPs 的快速聚集，并同时释放亚甲基蓝作为光动力疗法 (PDT) 的光敏剂。在肿瘤环境中，聚集的金纳米颗粒确保更高的肿瘤积累和保留。此外，聚集的金纳米粒子吸收的红移导致近红外照射下激活的光声成像信号和光热治疗（PTT）。因此，Au-MB-PEG NPs 通过联合 PTT-PDT 疗法有效抑制肿瘤生长。这项工作有助于设计刺激诱导的尺寸聚集纳米药物，从而在癌症诊断和治疗中获得先进的性能。

更新日期：2021-09-09

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