Journal of Advanced Research ( IF 11.4 ) Pub Date : 2021-07-08 , DOI: 10.1016/j.jare.2021.07.002 Qichen Shen 1 , Zhuizui Huang 1 , Jiachen Yao 2 , Yuanxiang Jin 1
Background
The intestinal tract is a complicated ecosystem with dynamic homeostasis via interaction of intestine and microbiota. Inflammatory bowel disease (IBD) is chronic intestinal inflammation involving dysbiosis of intestinal microenvironment. Extracellular vesicles (EVs), as vital characteristics of cell–cell and cell-organism communication, contribute to homeostasis in intestine. Recently, EVs showed excellent potential for clinical applications in disease diagnoses and therapies.
Aim of Review
Our current review discusses the modulatory functions of EVs derived from different sources in intestine, especially their effects and applications in IBD clinical therapy. EV-mediated interaction systems between host intestine and microbiota were established to describe possible mechanisms of IBD pathogenesis and its cure.
Key Scientific Concepts of Review
EVs are excellent vehicles for delivering molecules containing genetic information to recipient cells. Multiple pieces of evidence have illustrated that EVs participate the interaction between host and microbiota in intestinal microenvironment. In inflammatory intestine with dysbiosis of microbiota, EVs as regulators target promoting immune response and microbial reconstruction. EVs-based immunotherapy could be a promising therapeutic approach for the treatment of IBD in the near future.
中文翻译:
细胞外囊泡介导的炎症性肠病肠道微环境内的相互作用
背景
肠道是一个复杂的生态系统,通过肠道和微生物群的相互作用动态平衡。炎症性肠病(IBD)是一种慢性肠道炎症,涉及肠道微环境的失调。细胞外囊泡 (EVs) 作为细胞间和细胞间通讯的重要特征,有助于肠道内的稳态。最近,电动汽车在疾病诊断和治疗的临床应用中显示出巨大的潜力。
审查目的
我们目前的综述讨论了肠道中不同来源的 EV 的调节功能,特别是它们在 IBD 临床治疗中的作用和应用。建立了 EV 介导的宿主肠道和微生物群之间的相互作用系统,以描述 IBD 发病机制及其治疗的可能机制。
审查的关键科学概念
电动汽车是向受体细胞传递包含遗传信息的分子的极好工具。多项证据表明,EV参与了肠道微环境中宿主与微生物群之间的相互作用。在具有微生物群失调的炎症性肠道中,作为调节剂的 EVs 旨在促进免疫反应和微生物重建。在不久的将来,基于 EV 的免疫疗法可能是治疗 IBD 的一种有前途的治疗方法。