Achieving “mixed-product removal” in a mixed-suspension mixed-product removal crystallizer (MSMPRC), operating with a pressure-driven suspension transfer, is challenging. In this work, single and multiphase computational fluid dynamics (CFD) simulations were used to guide the choice of a suitable withdrawal position, which was found to be that of an immersed tube close to the vessel wall. The chosen withdrawal position was then tested and compared to other withdrawal positions experimentally. It performed as predicted, whereas for the other positions, the degree of dilution (size-independent classification) and of sieving (size-dependent classification) of the product removed increased. Furthermore, the influence of a non-representative withdrawal on an MSMPRC steady-state was investigated using a population balance equation (PBE) model.

在压力驱动的悬浮液转移操作的混合悬浮液混合产品去除结晶器 (MSMPRC) 中实现“混合产品去除”具有挑战性。在这项工作中，单相和多相计算流体动力学 (CFD) 模拟用于指导选择合适的取出位置，发现该位置是靠近血管壁的浸入管的位置。然后测试所选的撤回位置并通过实验与其他撤回位置进行比较。它按预期执行，而对于其他位置，去除的产品的稀释度（与尺寸无关的分类）和筛分（与尺寸有关的分类）增加。此外，使用人口平衡方程 (PBE) 模型研究了非代表性退出对 MSMPRC 稳态的影响。