Conventional N-alkylation methods have been limited to approaches with high energy barriers and low selectivity. In this issue of Chem, MacMillan and co-workers report an innovative halogen abstraction-radical capture (HARC) strategy via metallaphotoredox catalysis that couples strained and hindered alkyl halides with a diverse range of N-nucleophiles.

中文翻译：

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通过 HARC 策略重新构想 C(sp ³ )–N 键的形成

传统的N-烷基化方法仅限于具有高能垒和低选择性的方法。在本期Chem 中，MacMillan 及其同事报告了一种创新的卤素提取-自由基捕获 (HARC) 策略，该策略通过金属光氧化还原催化将应变和受阻的烷基卤与各种N-亲核试剂结合。