Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2021-07-08 , DOI: 10.1080/10286020.2021.1946042 Bei-Ye Yang 1 , Wei-Guang Sun 1 , Jun-Jun Liu 1 , Jian-Ping Wang 1 , Zheng-Xi Hu 1 , Yong-Hui Zhang 1
Abstract
A new pair of enantiomeric isoprenylated chromone derivatives, (±)-pestaloficiol X [(±)-1], along with a known compound pestaloficiol J (2), were isolated from the plant endophytic fungus Pestalotiopsis sp. The racemic mixture 1 was separated through chiral HPLC. The structures of new compounds (±)-1 were elucidated on the basis of extensive spectroscopic data and their absolute configurations were further configured through computational analysis of their electronic circular dichroism (ECD) spectra. Compound (+)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC50 values of 1.35 ± 0.15 and 3.70 ± 0.33 μM, respectively, while compound (–)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC50 values of 2.39 ± 0.26 and 2.99 ± 0.35 μM, respectively.
中文翻译:
来自 Pestalotiopsis sp. 的一对新的细胞毒性对映异构异戊二烯色酮衍生物。
摘要
从植物内生真菌Pestalotiopsis sp.中分离出一对新的对映异构异戊二烯色酮衍生物,(±)-pestaloficiol X [(±)- 1 ],以及已知的化合物pestaloficiol J ( 2 )。通过手性HPLC分离外消旋混合物1 。基于广泛的光谱数据阐明了新化合物(±) -1的结构,并通过对其电子圆二色谱(ECD)光谱的计算分析进一步配置了它们的绝对构型。化合物 (+)- 1对 HL-60 和 HEP-3B 细胞系显示出显着的抑制效力,IC 50值分别为 1.35 ± 0.15 和 3.70 ± 0.33 μM,而化合物 (-)- 1对 HL-60 和 HEP-3B 细胞系显示出显着的抑制效力,IC 50值分别为 2.39 ± 0.26 和 2.99 ± 0.35 μM .