Abstract

A new pair of enantiomeric isoprenylated chromone derivatives, (±)-pestaloficiol X [(±)-1], along with a known compound pestaloficiol J (2), were isolated from the plant endophytic fungus Pestalotiopsis sp. The racemic mixture 1 was separated through chiral HPLC. The structures of new compounds (±)-1 were elucidated on the basis of extensive spectroscopic data and their absolute configurations were further configured through computational analysis of their electronic circular dichroism (ECD) spectra. Compound (+)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC₅₀ values of 1.35 ± 0.15 and 3.70 ± 0.33 μM, respectively, while compound (–)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC₅₀ values of 2.39 ± 0.26 and 2.99 ± 0.35 μM, respectively.

摘要

从植物内生真菌Pestalotiopsis sp.中分离出一对新的对映异构异戊二烯色酮衍生物，(±)-pestaloficiol X [(±)- 1 ]，以及已知的化合物pestaloficiol J ( 2 )。通过手性HPLC分离外消旋混合物1 。基于广泛的光谱数据阐明了新化合物(±) -1的结构，并通过对其电子圆二色谱(ECD)光谱的计算分析进一步配置了它们的绝对构型。化合物 (+)- 1对 HL-60 和 HEP-3B 细胞系显示出显着的抑制效力，IC ₅₀值分别为 1.35 ± 0.15 和 3.70 ± 0.33 μM，而化合物 (-)- 1对 HL-60 和 HEP-3B 细胞系显示出显着的抑制效力，IC ₅₀值分别为 2.39 ± 0.26 和 2.99 ± 0.35 μM .