Organic unsymmetrical disulfides have been extensively applied in various academic and industrial fields including intermediates in organic synthesis, agriculture, and food science, natural materials, biochemistry, pharmaceutical and medicine chemistry, polymers, material engineering, etc. They play a crucial role in the fabrication of various biological active sulfur heterocycles. Due to broad and extensive applications, many methods have been developed for the synthesis of unsymmetrical S−S and efforts have been made to improve some issues such as cost, energy efficiency, green chemistry, avoid or minimizing waste generation. Several outstanding review articles have been previously published highlighting the advances of S−S bond formation, in general, using various reagents under different conditions in the absence or presence of oxidants/catalysts. In 2020, a review paper was published by our group focusing on recent developments since 2014 in the synthesis of organic symmetrical disulfides. However, investigations on new catalytic methods are being regularly reported and new types of unsymmetrical disulfides are synthesized. The present overview has attempted to systematically summarize recent advances in the process of unsymmetrical S−S bond formation with a major focus since 2010, highlighting mechanistic considerations, substrate scope, advantages, and limitations. The patents are not studied in this overview.

中文翻译：

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有机不对称二硫化物合成新进展综述

有机不对称二硫化物已广泛应用于各种学术和工业领域，包括有机合成中间体、农业和食品科学、天然材料、生物化学、药物和药物化学、聚合物、材料工程等. 它们在各种生物活性硫杂环的制造中起着至关重要的作用。由于广泛和广泛的应用，已经开发了许多合成不对称 S-S 的方法，并努力改善成本、能源效率、绿色化学、避免或减少废物产生等问题。之前已经发表了几篇杰出的评论文章，强调了 S-S 键形成的进展，一般来说，在不存在或存在氧化剂/催化剂的情况下，在不同条件下使用各种试剂。2020 年，我们小组发表了一篇综述论文，重点介绍了 2014 年以来有机对称二硫化物合成方面的最新进展。然而，对新催化方法的研究正在定期报道，并合成了新型的不对称二硫化物。本综述试图系统地总结自 2010 年以来不对称 S-S 键形成过程的最新进展，重点关注机械方面的考虑、底物范围、优势和局限性。本概述中不研究这些专利。