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New tricks for the old autophagy protein Atg8
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2021-07-08 , DOI: 10.1038/s41594-021-00618-1
Eeva-Liisa Eskelinen 1
Affiliation  

The autophagy protein Atg8 regulates autophagosome biogenesis and mediates cargo recruitment in different types of selective autophagy, but the molecular mechanisms mediating Atg8 functions during autophagosome biogenesis have been unclear. A study published in Nature Structural & Molecular Biology now shows that lipidated Atg8 possesses physicochemical activity that regulates membrane morphology, which underlies efficient autophagosome biogenesis.

中文翻译:

旧自噬蛋白 Atg8 的新技巧

自噬蛋白 Atg8 调节自噬体生物发生并介导不同类型选择性自噬中的货物募集,但在自噬体生物发生过程中介导 Atg8 功能的分子机制尚不清楚。现在,发表在《自然结构与分子生物学》(Nature Structural & Molecular Biology) 上的一项研究表明,脂质化的 Atg8 具有调节膜形态的物理化学活性,这是有效自噬体生物发生的基础。
更新日期:2021-07-08
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