Abstract

Background

We have investigated the role of a cardiomyokine, follistatin-like 1 (FSTL1), and its single nucleotide polymorphism on acromegalic cardiomyopathy.

Methods

The study was performed as a cross-sectional case research in a Tertiary Referral Centre. Forty-six patients with acromegaly (29 F–17 M, mean age: 50.3 ± 12.1 years) were included. FSTL1 levels were measured and the rs1259293 region of the FSTL1 gene was subjected to polymorphism analysis. 1.5 Tesla MRI was used to obtain cardiac images.

Results

There were 15 active (6 F–9M) and 31 (22 F–9M) controlled patients. Active patients had a higher left ventricular mass (LVM) and left ventricular mass index (LVMi). GH levels were positively correlated with left ventricular end-diastolic volume index (LVEDVi), stroke volume index (SVi), cardiac index (Ci), LVM and LVMi; r = 0.35, 0.38, 0.34, 0.39 and 0.39, respectively. IGF-1 index was positively correlated with LVEDVi, left ventricular end-systolic volume index (LVESVi), SVi, Ci, LVM and LVMi; r = 0.36, 0.34, 0.32, 0.31, 0.42 and 0.42, respectively. Twenty out of 46 patients with acromegaly (43.5%) had myocardial fibrosis. FSTL1 levels were neither correlated with disease activity nor with any functional and structural cardiac parameter. Multivariate linear regression analysis revealed no association between FSTL1 and any study parameters. The rs1259293 variant genotype CC was significantly associated with low left ventricular mass.

Conclusions

Serum FSTL1 levels are not associated with functional and structural measures of myocardium in patients with acromegaly. However, the risk of left ventricular hypertrophy is reduced in CC genotyped individuals of FSTL1.

中文翻译：

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特定的 FSTL1 多态性可能决定肢端肥大症患者患心肌病的风险

摘要

背景

我们研究了心肌因子、卵泡抑素样 1 (FSTL1) 及其单核苷酸多态性对肢端肥大症心肌病的作用。

方法

该研究是在三级转诊中心作为横断面案例研究进行的。包括 46 名肢端肥大症患者（29 F-17 M，平均年龄：50.3 ± 12.1 岁）。测量 FSTL1 水平并对 FSTL1 基因的 rs1259293 区域进行多态性分析。1.5 Tesla MRI 用于获取心脏图像。

结果

有 15 名活动患者（6 F-9M）和 31 名（22 F-9M）对照患者。活跃患者的左心室质量 (LVM) 和左心室质量指数 (LVMi) 较高。GH水平与左心室舒张末期容积指数（LVEDVi）、每搏输出量指数（SVi）、心脏指数（Ci）、LVM和LVMi呈正相关；r  = 0.35、0.38、0.34、0.39 和 0.39，分别。IGF-1指数与LVEDVi、左心室收缩末期容积指数（LVESVi）、SVi、Ci、LVM和LVMi呈正相关；r = 0.36、0.34、0.32、0.31、0.42 和 0.42，分别。46 名肢端肥大症患者中有 20 名（43.5%）患有心肌纤维化。FSTL1 水平既不与疾病活动相关，也不与任何功能和结构心脏参数相关。多元线性回归分析显示 FSTL1 与任何研究参数之间没有关联。rs1259293 变异基因型 CC 与低左心室质量显着相关。

结论

血清 FSTL1 水平与肢端肥大症患者心肌的功能和结构测量无关。然而，在 FSTL1 的 CC 基因型个体中，左心室肥大的风险降低。