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Serum triglyceride levels and related factors as prognostic indicators in COVID-19 patients: A retrospective study
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2021-07-08 , DOI: 10.1002/iid3.469
Peng Zhong 1 , Zhenzhou Wang 2 , Zhe Du 2
Affiliation  

The role of triglycerides (TG) in coronavirus disease (COVID-19) is controversial. The objective of this study was to explore the relationship between TG levels and prognosis in COVID-19 patients and investigate the factors that affect TG. COVID-19 patients were divided into normal or high TG level groups. Their demographic data, medical history, signs and symptoms, laboratory results, and final clinical results were analyzed retrospectively. A total of 174 patients were included. TG level was 1.6 (interquartile range [IQR]: 1.1‒2.1) mmol/L for all patients; 2.2 (IQR: 1.8‒2.7) mmol/L and 1.1 (IQR: 1.0–1.3) mmol/L in the high TG and control groups, respectively. Overall, 29 patients (16.7%) died during hospitalization, including 19 (23.1%) in the high TG group and 10 (11.5%) in the control group (absolute survival difference, 2.5% (95% confidence interval [CI], 1.2%-5.1%), log-rank χ 2 = 5.7, and p = .017). Serum ferritin, C-reactive protein (CRP), lactate dehydrogenase (LDH), and interleukin-10 (IL-10) levels were significantly higher in the high TG group compared to the control group. Pearson correlation analysis showed that TG was positively correlated with fasting blood glucose, leukocyte, serum ferritin, LDH, CRP, and IL-10 levels. Multiple regression showed that serum ferritin and IL-10 levels affected the TG level (R 2 = .095). The TG level in COVID-19 patients is correlated to serum ferritin and IL-10 levels, which reflects the activation of macrophages. It is suggested that COVID-19 patients be monitored for elevated TG as both a prognostic indicator and potential therapeutic target for COVID-19.

中文翻译:

血清甘油三酯水平及相关因素作为 COVID-19 患者预后指标:一项回顾性研究

甘油三酯 (TG) 在冠状病毒病 (COVID-19) 中的作用存在争议。本研究的目的是探讨 COVID-19 患者 TG 水平与预后之间的关系,并调查影响 TG 的因素。COVID-19 患者被分为正常或高 TG 水平组。回顾性分析了他们的人口统计学数据、病史、体征和症状、实验室结果和最终临床结果。共纳入 174 名患者。所有患者的TG水平为1.6(四分位距[IQR]:1.1-2.1)mmol/L;高TG组和对照组分别为2.2(IQR:1.8-2.7)mmol/L和1.1(IQR:1.0-1.3)mmol/L。总体而言,29 名患者(16.7%)在住院期间死亡,其中高 TG 组 19 名(23.1%)和对照组 10 名(11.5%)(绝对生存差异,2.χ 2  = 5.7,并且p  = .017)。与对照组相比,高 TG 组的血清铁蛋白、C 反应蛋白 (CRP)、乳酸脱氢酶 (LDH) 和白细胞介素 10 (IL-10) 水平显着更高。Pearson相关分析显示TG与空腹血糖、白细胞、血清铁蛋白、LDH、CRP、IL-10水平呈正相关。多元回归显示血清铁蛋白和 IL-10 水平影响 TG 水平 ( R 2  = .095)。COVID-19 患者的 TG 水平与血清​​铁蛋白和 IL-10 水平相关,反映了巨噬细胞的活化。建议监测 COVID-19 患者的 TG 升高,作为 COVID-19 的预后指标和潜在治疗靶点。
更新日期:2021-08-07
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