Toxoplasma gondii and Mycobacterium tuberculosis are intracellular pathogens, both infecting a substantial proportion of human population. We conducted a systematic review and meta-analysis to estimate the pooled T. gondii seroprevalence in tuberculosis patients. Three international databases were systematically searched for literature on prevalence of T. gondii in tuberculosis patients. A total of 1389 documents were identified, and eight papers were eligible to be included in the systematic review and meta-analysis. Geographical data gaps were evident, as no studies were identified from many countries where both infections are important. The pooled seroprevalence of IgG, IgM, and both IgG and IgM antibodies against T. gondii in tuberculosis patients were estimated to be 35.9% (95% confidence interval [CI], 19.3–56.7%), 35.0% (95% CI, 3.0–90.3%), and 13.4% (95% CI, 2.4–49.0%), respectively. In the included case-control studies, the pooled T. gondii seroprevalence (proportion anti- T. gondii IgG antibody positive) was higher in tuberculosis patients than in their controls, with an odds ratio by random effects model of 1.63 (95% CI, 1.28–2.08). The results of our work suggest an association between T. gondii seropositivity and being a tuberculosis patient, which should however be interpreted with caution because the timeline of the infections and the disease process are not accounted for. Our work showed that T. gondii seropositivity, indicating chronic infection with the zoonotic parasite, was relatively common among tuberculosis patients.

弓形虫和结核分枝杆菌是细胞内病原体，都感染了相当大比例的人群。我们进行了一项系统评价和荟萃分析，以估计结核病患者中合并的弓形虫血清阳性率。系统地搜索了三个国际数据库，以查找有关结核病患者中弓形虫流行情况的文献。共检索到 1389 篇文献，其中 8 篇论文符合纳入系统评价和荟萃分析的条件。地理数据差距很明显，因为在这两种感染都很重要的许多国家中，没有发现任何研究。IgG、IgM 以及针对弓形虫的IgG 和 IgM 抗体的合并血清阳性率在结核病患者中估计为 35.9%（95% 置信区间 [CI]，19.3-56.7%）、35.0%（95% CI，3.0-90.3%）和 13.4%（95% CI，2.4-49.0%） ， 分别。在纳入的病例对照研究中，结核病患者的合并弓形虫血清阳性率（抗弓形虫IgG 抗体阳性的比例）高于对照组，随机效应模型的优势比为 1.63（95% CI， 1.28–2.08）。我们的工作结果表明，弓形虫血清阳性与结核病患者之间存在关联，但应谨慎解释，因为未考虑感染的时间线和疾病过程。我们的工作表明，刚地弓形虫 血清阳性表明慢性感染人畜共患寄生虫，在结核病患者中相对常见。