Objectives The objective of this study is to investigate the cardiovascular risk factors associated with metabolic syndrome (MetS), which is increasingly becoming prevalent in childhood obesity. Methods A total of 113 patients, 76 of whom were between the ages of 10 and 17 (mean age: 14.5 ± 1.8 years) and diagnosed with obesity (30 non-MetS and 46 MetS using IDF) and 37 of whom constituted the control group, participated in the study. Echocardiographic examination and atherogenicity parameters (Atherogenic index of plasma [AIP: logTG/HDL], total cholesterol/HDL, and TG/HDL ratio and non-HDL) were evaluated. Results The most common component accompanying obese MetS was found to be hypertension and low HDL. While obesity duration, body mass index (BMI), blood pressure, fasting insulin, insulin resistance, atherogenicity parameters were determined to be significantly higher in the obese-MetS group. Echocardiography showed that while the thickness, volume, and diameter of LV end-diastolic wall, left ventricular mass (LVM), LVM index (LVMI g/m 2 ) and relative wall thickness (RWT) were significantly high in the MetS group, however, mitral E/A ratio was significantly lower (p<0.05). Change in LV geometry consistent with concentric remodeling (increased RWT, normal LVMI) was visible in obese groups. LVM were positively significantly related to BMI, waist circumference, insulin resistance, blood pressure, LDL level, and negative to mitral E/A ratio. In the obese-MetS group, LVMI was positively correlated to office systolic BP, left atrium end-diastolic volume/index. Conclusions LVMI and atherogenicity parameters that were found to be significantly higher in obese MetS exhibit increased cardiovascular risk in childhood.

中文翻译：

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儿童期代谢综合征肥胖患者心血管危险因素患病率调查及超声心动图左室功能检查

目的 本研究的目的是调查与代谢综合征 (MetS) 相关的心血管危险因素，代谢综合征在儿童肥胖症中越来越普遍。方法 113 例患者，其中 76 例年龄在 10 至 17 岁之间（平均年龄：14.5±1.8 岁）并被诊断为肥胖（30 例非 MetS 和 46 例使用 IDF 的 MetS），37 例构成对照组，参与了研究。评估超声心动图检查和致动脉粥样硬化参数（血浆致动脉粥样硬化指数 [AIP：logTG/HDL]、总胆固醇/HDL、TG/HDL 比率和非 HDL）。结果 发现伴随肥胖 MetS 的最常见成分是高血压和低 HDL。而肥胖持续时间、体重指数 (BMI)、血压、空腹胰岛素、胰岛素抵抗、肥胖-MetS 组的致动脉粥样硬化参数明显更高。超声心动图显示，虽然 MetS 组的 LV 舒张末期壁的厚度、体积和直径、左心室质量 (LVM)、LVM 指数 (LVMI g/m 2 ) 和相对壁厚 (RWT) 显着较高，但, 二尖瓣 E/A 比值显着降低 (p<0.05)。与同心重构一致的 LV 几何变化（增加的 RWT，正常的 LVMI）在肥胖组中可见。LVM 与 BMI、腰围、胰岛素抵抗、血压、低密度脂蛋白水平和负二尖瓣 E/A 比值呈显着正相关。在肥胖-MetS 组中，LVMI 与诊室收缩压、左心房舒张末期容积/指数呈正相关。