Abstract

The current study focuses on the preparation of sericin and silk fibroin blend electrostatic spinning fiber film dressing. The surface morphology of the fiber films was observed by scanning electron microscope, and the hydrophilicity and swelling property of the fiber membrane dressing were analyzed. The biocompatibility of the four dressings was verified by the CCK-8 method and confocal laser microscopy. This experiment showed that the dressing group with the ratio of sericin to silk fibroin of 3:7 had better performance, offering fine and uniform fiber structure, good surface hydrophilicity, high water vapor transmission rate. The swelling rate of it was 822.77 ± 62.78%, and the tensile properties reached the requirements of dressing materials and had an excellent ability to promote cell adhesion and proliferation. This paper provides a possible method for producing of dressing materials with good hydrophilicity and high moisture vapor transmission rate.

摘要

目前的研究重点是丝胶和丝素蛋白共混静电纺丝纤维薄膜敷料的制备。通过扫描电镜观察纤维膜的表面形貌，分析了纤维膜敷料的亲水性和溶胀性。四种敷料的生物相容性通过CCK-8法和激光共聚焦显微镜验证。本实验表明，丝胶与丝素比为3:7的敷料组性能更佳，纤维结构细腻均匀，表面亲水性好，透湿率高。其溶胀率为822.77±62.78%，拉伸性能达到敷料材料的要求，具有优异的促进细胞粘附和增殖能力。