ABSTRACT

Background

Our study aimed to determine the profile of Guillain–Barré syndrome (GBS) in the Philippines, compare the outcomes who received intravenous immunoglobulin (IVIg) and therapeutic plasma exchange (TPE), and determine the factors related to hospital stay and late motor recovery.

Methods

We conducted a retrospective cohort study of adult GBS patients admitted to the Philippine General Hospital from 2009 to 2019.

Results

We included 105 patients with confirmed GBS diagnoses. The median age was 43 years (interquartile range 32 to 56); the female-to-male ratio was 1.62:1; the predominant variant was acute inflammatory demyelinating polyneuropathy (n = 40, 38.1%). The difference in outcomes of patients in the IVIg (n = 44) and TPE (n = 24) groups (walking with aid/GBS-disability scores/ventilator dependency at 1 month, duration dependent on the ventilator, intensive care unit stay, and hospital stay) were not statistically significant, except for mild disability at 1 month (p = 0.009). Pneumonia, urinary tract infection, and dysautonomia were significantly related to a prolonged hospital stay. No predetermined variables were associated with late motor recovery. After adjusting for age and sex, the cumulative hazard risk for late motor recovery was 0.69 (95% CI 0.27–1.74).

Conclusion

Our study presented the first comprehensive information regarding the features and outcomes of GBS patients in the Philippines.

Abbreviations

AIDP – Acute inflammatory demyelinating polyneuropathy; AMAN – Acute motor axonal neuropathy; AMSAN – Acute motor and sensory axonal neuropathy; GBS – Guillain–Barré syndrome; GBS-DS – Guillain–Barré syndrome disability scale; ICU – Intensive care unit; IVIg – Intravenous immunoglobulin; MFS – Miller–Fisher syndrome; PGH – Philippine General Hospital; TPE – Therapeutic plasma exchange.

中文翻译：

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菲律宾格林-巴利综合征的临床特征和真实世界结果

摘要

背景

我们的研究旨在确定菲律宾格林-巴利综合征 (GBS) 的概况，比较接受静脉注射免疫球蛋白 (IVIg) 和治疗性血浆置换 (TPE) 的结果，并确定与住院时间和晚期运动恢复相关的因素。

方法

我们对 2009 年至 2019 年在菲律宾总医院收治的成年 GBS 患者进行了一项回顾性队列研究。

结果

我们纳入了 105 名确诊为 GBS 的患者。中位年龄为 43 岁（四分位距为 32 至 56）；男女比例为1.62:1；主要变异是急性炎症性脱髓鞘性多发性神经病（n = 40, 38.1%）。IVIg (n = 44) 和 TPE (n = 24) 组患者结局的差异（在 1 个月时借助辅助行走/GBS 残疾评分/对呼吸机的依赖、依赖于呼吸机的持续时间、重症监护病房的住院时间，以及住院时间）没有统计学意义，除了 1 个月的轻度残疾（p = 0.009）。肺炎、尿路感染和自主神经功能障碍与住院时间延长显着相关。没有预先确定的变量与晚期运动恢复相关。调整年龄和性别后，晚期运动恢复的累积危险风险为 0.69（95% CI 0.27–1.

结论

我们的研究首次提供了关于菲律宾 GBS 患者特征和结果的综合信息。

缩写

AIDP——急性炎症性脱髓鞘性多发性神经病；AMAN – 急性运动轴索性神经病；AMSAN – 急性运动和感觉轴索神经病；GBS——格林-巴利综合征；GBS-DS – 格林-巴利综合征残疾量表；ICU——重症监护室；IVIg – 静脉注射免疫球蛋白；MFS——米勒-费舍尔综合征；PGH——菲律宾总医院；TPE – 治疗性血浆置换。