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Chemical Composition and Biological Activities of Leaf Essential Oil of Syzygium myrtifolium from Eastern India
Journal of Essential Oil Bearing Plants ( IF 2.1 ) Pub Date : 2021-07-06 , DOI: 10.1080/0972060x.2021.1947897
Sudipta Jena 1 , Asit Ray 1 , Ambika Sahoo 1 , Prabhat Kumar Das 2 , Khirabdhi Tanaya Dash 1 , Subrat Kumar Kar 3 , Sanghamitra Nayak 1 , Pratap Chandra Panda 1
Affiliation  

Abstract

The chemical composition, antioxidant, cytotoxicity and anti-inflammatory activities of leaf essential oil of Syzygium myrtifolium Walp. was evaluated in the present study. A total of 43 constituents representing 96.99 % of the total essential oil were identified by GC/MS analysis. The leaf essential oil was mainly characterized by sesquiterpene incorporate alcohols (34.99 %) with δ-cadinol (29.53 %), caryophyllene oxide (26.25 %) and cyclocolorenone (7.7 %) as the major constituents. The antioxidant activity of the leaf essential oil against DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)) assays showed IC50 values of 215 ± 4.61 and 116 ± 2.37 μg/mL respectively. In vitro cytotoxic effect of the essential oil evaluated against HCT-116 and Pa-1 cell lines by MTT [3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide] assay showed IC50 values of 59.9 and 47.5 μg/mL respectively. Further, the leaf essential oil at a concentration of 25 μg/mL was found to exhibit potential anti-inflammatory activity in lipopolysaccharide-activated RAW 264.7 macrophages by inhibiting nitric oxide (NO) production. The findings of the present study revealed that the leaf essential oil of S. myrtifolium is a rich source of bioactive constituents, which needs further investigation as leads for anti-inflammatory and anti-cancer drug discovery.



中文翻译:

东印度丁香叶精油的化学成分及生物活性

摘要

Syzygium myrtifolium Walp叶精油的化学成分、抗氧化、细胞毒性和抗炎活性。在本研究中进行了评估。通过 GC/MS 分析鉴定了总共 43 种成分,占总精油的 96.99%。叶精油的主要特征是倍半萜醇(34.99%),δ-卡地诺(29.53%)、石竹烯氧化物(26.25%)和环色酮(7.7%)为主要成分。叶精油对 DPPH (2,2-diphenyl-1-picrylhydrazyl) 和 ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)) 的抗氧化活性测定表明 IC 50值为 215分别为 ± 4.61 和 116 ± 2.37 μg/mL。体外通过 MTT [3-(4, 5-二甲基噻唑基-2)-2,5-二苯基溴化四唑] 测定评估精油对 HCT-116 和 Pa-1 细胞系的细胞毒性作用显示 IC 50值为 59.9 和 47.5 μg/毫升分别。此外,发现浓度为 25 μg/mL 的叶精油通过抑制一氧化氮 (NO) 的产生,在脂多糖激活的 RAW 264.7 巨噬细胞中表现出潜在的抗炎活性。本研究结果表明,桃金娘叶精油是生物活性成分的丰富来源,需要进一步研究作为抗炎和抗癌药物发现的线索。

更新日期:2021-07-21
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