Cerebrovascular reactivity (CVR) deficits in adolescents with concussion may persist after resolution of neurological symptoms. Whether or not CVR deficits predict long term neurological function is unknown. We used adolescent mice closed head injury (CHI) models (54 g, 107 cm or 117 cm drop height), followed by blood oxygenation level dependent (BOLD)-functional MRI with CO₂ challenge to assess CVR and brain connectivity. At one week, 3HD 107 cm mice showed delayed BOLD responses (p = 0.0074), normal striatal connectivity_, and an impaired respiratory rate response to CO₂ challenge (p = 0.0061 in ΔRmax). The 107 cm group developed rotarod deficits at 6 months (p = 0.02) and altered post-CO₂ brain connectivity (3-fold increase in striatum to motor cortex correlation coefficient) by one year, but resolved their CVR and respiratory rate impairments, and did not develop cognitive or circadian activity deficits. In contrast, the 117 cm group had persistent CVR (delay time: p = 0.016; washout time: p = 0.039) and circadian activity deficits (free-running period: 23.7 hr in sham vs 23.9 hr in 3HD; amplitude: 0.15 in sham vs 0.2 in 3HD; peak activity: 18 in sham vs 21 in 3HD) at one year. Persistent CVR deficits after concussion may portend long-term neurological dysfunction. Further studies are warranted to determine the utility of CVR to predict chronic neurological outcome after mild traumatic brain injury.

患有脑震荡的青少年的脑血管反应性 (CVR) 缺陷在神经系统症状消退后可能会持续存在。CVR 缺陷是否能预测长期神经功能尚不清楚。_{我们使用青春期小鼠闭合性头部损伤 (CHI) 模型（54 g、107 cm 或 117 cm 跌落高度），然后使用 CO 2}挑战的血氧水平依赖性 (BOLD) 功能 MRI来评估 CVR 和大脑连接性。在一周内，3HD 107 cm 小鼠表现出延迟的 BOLD 反应 (p = 0.0074)、正常的纹状体连接_以及对 CO ₂挑战的呼吸频率反应受损（ΔRmax 中 p = 0.0061）。107 cm 组在 6 个月时出现转棒缺陷 (p = 0.02) 并在 CO _{2后发生改变}大脑连通性（纹状体与运动皮层相关系数增加 3 倍）一年，但解决了他们的 CVR 和呼吸频率障碍，并且没有出现认知或昼夜节律活动缺陷。相比之下，117 cm 组有持续的 CVR（延迟时间：p = 0.016；清除时间：p = 0.039）和昼夜节律活动缺陷（自由运行期：假手术中为 23.7 小时，而 3HD 中为 23.9 小时；幅度：假手术中为 0.15与 3HD 中的 0.2；峰值活动：一年内 18 与 3HD 中的 21 相比。脑震荡后持续的 CVR 缺陷可能预示着长期的神经功能障碍。需要进一步的研究来确定 CVR 在预测轻度创伤性脑损伤后慢性神经系统预后方面的效用。