The calcium‑phosphorus ratio (Ca/P) has an important role in calcium phosphate applications, as a slight change in this ratio results in substantial modifications of their characteristics. Hydroxyapatite is a bioactive ceramic of the calcium phosphate family, and its composition and crystalline structure are similar to the human bone. For this reason, it is widely used to promote bone integration in prosthetics and scaffolds. Prosthetics are usually made of metal and coated with bioceramics and the some techniques used to make these coatings depositions conserve the stoichiometry from the target during deposition. Therefore, studying the target Ca/P is a way to guaranteeing the final deposition stoichiometry. In this study, we investigated the One Point Calibration – Laser Induced Breakdown Spectroscopy (OPC-LIBS) method for the measurement of the Ca/P of hydroxyapatite targets. This method is quantitative, based on the determination of correction parameters via analysis of a standard sample with known stoichiometry. Results were compared to well-established techniques of X-ray Fluorescence (XRF) and Atomic Absorption Spectroscopy (AAS) and showed that the deviation in the difference is less than 5%, proposing a substitute for elemental analysis. Moreover, this method has technical advantages such as rapid measurements, no need for sample preparation or destruction and easy automation.

钙磷比 (Ca/P) 在磷酸钙应用中具有重要作用，因为该比例的微小变化会导致其特性发生重大变化。羟基磷灰石是磷酸钙家族的生物活性陶瓷，其成分和晶体结构与人体骨骼相似。因此，它被广泛用于促进假肢和支架中的骨整合。假肢通常由金属制成并涂有生物陶瓷，用于制造这些涂层沉积的一些技术在沉积过程中保留了目标的化学计量。因此，研究目标 Ca/P 是保证最终沉积化学计量的一种方式。在这项研究中，我们研究了用于测量羟基磷灰石目标 Ca/P 的单点校准 - 激光诱导击穿光谱 (OPC-LIBS) 方法。该方法是定量的，基于通过分析具有已知化学计量的标准样品来确定校正参数。结果与 X 射线荧光 (XRF) 和原子吸收光谱 (AAS) 的成熟技术进行了比较，结果表明差异的偏差小于 5%，建议替代元素分析。此外，该方法具有测量快速、无需样品制备或破坏、易于自动化等技术优势。结果与 X 射线荧光 (XRF) 和原子吸收光谱 (AAS) 的成熟技术进行了比较，结果表明差异的偏差小于 5%，建议替代元素分析。此外，该方法具有测量快速、无需样品制备或破坏、易于自动化等技术优势。结果与 X 射线荧光 (XRF) 和原子吸收光谱 (AAS) 的成熟技术进行了比较，结果表明差异的偏差小于 5%，建议替代元素分析。此外，该方法具有测量快速、无需样品制备或破坏、易于自动化等技术优势。