Peak oxygen pulse (O₂ pulse_peak) may have predictive utility for health outcomes yet, presently, has only been examined in men and only using a single baseline measure.

Purpose

The primary aim of this investigation was to evaluate the relationship between O₂ pulse_peak and all-cause mortality in apparently healthy women and men. A secondary aim was to explore the relationship between longitudinal changes to O₂ pulse_peak and mortality.

Methods

The sample included 3877 participants (43% women) for the primary aim and 759 participants (32% women) who performed two cardiopulmonary exercise tests ≥1 year apart for the secondary aim. Cox proportional hazard models were performed to determine the relationship between O₂ pulse_peak and mortality. Prognostic peak oxygen consumption (VO_2peak) and O₂ pulse_peak models were compared using the concordance index and Akaike information criterion (AIC).

Results

In the assessment from baseline, there were 730 deaths over a 24.7 ± 11.8 year follow-up period. For men, a single measure of O₂ pulse_peak was inversely associated with risk for mortality (P < 0.05). However, the concordance index and AIC indicated lower discrimination compared to VO_2peak models and O₂ pulse_peak did not provide complementary benefit to VO_2peak models. For women, O₂ pulse_peak was not associated with mortality risk. In the longitudinal analysis, there were 168 deaths over a follow-up of 20.1 ± 11.4 years. Changes to O₂ pulse_peak were not significantly related to mortality in either sex.

Conclusions

Within an apparently healthy cohort, a single assessment of O₂ pulse_peak is related to all-cause mortality in men but not women. Further, longitudinal changes to O₂ pulse_peak are not predictive of mortality in either sex. These findings suggest O₂ pulse_peak may have limited prognostic utility in healthy individuals, particularly within healthy women.

中文翻译：

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健康女性和男性的峰值氧脉冲和死亡风险：Ball State 成人健身纵向生活方式研究 (BALL ST)

峰值氧脉冲（O ₂脉冲_峰值）可能对健康结果具有预测效用，但目前仅在男性中进行了检查，并且仅使用单一基线测量。

目的

这项调查的主要目的是评估 O ₂脉冲_峰值与明显健康的女性和男性的全因死亡率之间的关系。次要目的是探索 O ₂脉冲_峰值的纵向变化与死亡率之间的关系。

方法

样本包括 3877 名主要目标参与者（43% 女性）和 759 名参与者（32% 女性）为次要目标进行了两次心肺运动测试，这些测试间隔≥1 年。进行Cox比例风险模型以确定O ₂脉冲_峰值与死亡率之间的关系。使用一致性指数和 Akaike 信息标准 (AIC) 比较预后峰值耗氧量 (VO _2peak ) 和 O ₂脉冲_峰值模型。

结果

在基线评估中，在 24.7 ± 11.8 年的随访期内有 730 人死亡。对于男性，O ₂脉冲_峰值的单一测量与死亡风险呈负相关（P < 0.05）。然而，一致性指数和 AIC 表明与 VO _2peak模型相比具有较低的辨别_力，并且 O ₂脉冲_峰值没有为 VO _2peak模型提供补充优势。对于女性，O ₂脉冲_峰值与死亡风险无关。在纵向分析中，在 20.1 ± 11.4 年的随访期间有 168 人死亡。O ₂脉冲_{峰值的变化} 与任何性别的死亡率都没有显着相关性。

结论

在一个明显健康的队列中，O ₂脉冲_峰值的单一评估与男性的全因死亡率有关，但与女性无关。此外，O ₂脉冲_峰值的纵向变化不能预测任何性别的死亡率。这些发现表明，O ₂脉冲_峰值对健康个体的预后效用可能有限，尤其是在健康女性中。