Fructose metabolism and fructose kinase KHK–C/A are key factors in the development of lipid oversynthesis-promoted metabolic disorders and cancer. Here, we summarize and discuss the current knowledge about the specific features of fructose metabolism and the distinct roles of KHK–C and KHK–A in metabolic liver diseases and their relevant metabolic disorders and cancer, and we highlight the specific protein kinase activity of KHK–A in tumor development. In addition, different approaches that have been used to inhibit KHK and the exploration of KHK inhibitors in clinical treatment are introduced.

中文翻译：

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癌症和其他病理中的果糖和果糖激酶

果糖代谢和果糖激酶 KHK-C/A 是脂质过度合成促进的代谢紊乱和癌症发生的关键因素。在这里，我们总结和讨论了目前关于果糖代谢的具体特征以及 KHK-C 和 KHK-A 在代谢性肝病及其相关代谢紊乱和癌症中的独特作用的知识，并重点介绍了 KHK 的特定蛋白激酶活性–肿瘤发展中的A。此外，还介绍了已用于抑制KHK的不同方法以及KHK抑制剂在临床治疗中的探索。