Background

The incidence of acute cholecystitis has a seasonal peak in summer. However, the reason for such seasonality remains unclear. This retrospective cohort study was performed to examine the association between ambient temperature and acute cholecystitis.

Methods

We identified admissions for acute cholecystitis from January 2011 to December 2017 from a nationwide inpatient database in Japan. We performed a Poisson regression analysis to investigate the association between ambient temperature and admission for acute cholecystitis with adjustment for relative humidity, national holidays, day of the week, and year. We accounted for clustering of the outcome within prefectures using a generalized estimating equation.

Results

We analyzed 601 665 admissions for acute cholecystitis. With an ambient temperature of 5.0 °C–9.9 °C as a reference, Poisson regression showed that the number of admissions increased significantly with increasing temperature (highest above 30 °C; relative risk, 1.35; 95% confidence interval, 1.34–1.37). An ambient temperature of <5.0 °C was also associated with higher admission for acute cholecystitis than an ambient temperature of 5.0 °C–9.9 °C (relative risk, 1.23; 95% confidence interval, 1.21–1.25).

Conclusion

The present nationwide Japanese inpatient database study showed that high temperature (≥10.0 °C) and low temperature (<5.0 °C) were associated with increased admission for acute cholecystitis.

中文翻译：

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急性胆囊炎的环境温度和住院人数：日本全国住院患者数据库研究

背景

急性胆囊炎的发病在夏季有一个季节性高峰。然而，这种季节性的原因仍不清楚。这项回顾性队列研究旨在检查环境温度与急性胆囊炎之间的关系。

方法

我们从日本全国住院患者数据库中确定了 2011 年 1 月至 2017 年 12 月的急性胆囊炎入院情况。我们进行了泊松回归分析，以调查环境温度与急性胆囊炎入院之间的关系，并调整相对湿度、国定假日、星期几和年份。我们使用广义估计方程考虑了县内结果的聚类。

结果

我们分析了 601 665 例急性胆囊炎入院病例。以 5.0 °C–9.9 °C 的环境温度为参考，泊松回归显示入院人数随温度升高而显着增加（最高高于 30 °C；相对风险，1.35；95% 置信区间，1.34–1.37） . 与 5.0 °C–9.9 °C 的环境温度相比，<5.0 °C 的环境温度也与更高的急性胆囊炎入院率相关（相对风险，1.23；95% 置信区间，1.21–1.25）。

结论

目前日本全国住院患者数据库研究表明，高温（≥10.0°C）和低温（<5.0°C）与急性胆囊炎入院率增加有关。