Successful reproduction is very important for individuals and for society. Currently, the human health span and lifespan are the object of intense and productive investigation with great achievements, compared to the last century. However, reproduction span does not progress concomitantly with lifespan. Reproductive organs age, decreasing the levels of sexual hormones, which are protectors of health through their action on several organs of the body. Thus, this is the starting point of the organismal decay and infertility. This starting point is easily detected in women. In men, it goes under the surface, undetected, but it goes, nevertheless.

Regarding fertility, aging alters the hormonal equilibrium, decreases the potential of reproductive organs, diminishes the quality of the gametes and worsen the reproductive outcomes. All these events happen at a different pace and affecting different organs in women and men. The question is what molecular pathways are involved in reproductive aging and if there is a possible halting or even reversion of the aging events. Answers to all these points will be explained in the present review.

成功的繁殖对个人和社会都非常重要。目前，与上个世纪相比，人类的健康寿命和寿命是紧张而富有成效的研究对象。然而，繁殖时间不会随着寿命而增加。生殖器官老化，降低性激素水平，这些激素通过作用于身体的多个器官来保护健康。因此，这是有机体腐烂和不育的起点。这个起点很容易在女性身上发现。在男人身上，它潜伏在表面之下，未被发现，但它仍然存在。

关于生育能力，衰老会改变荷尔蒙平衡，降低生殖器官的潜力，降低配子的质量并恶化生殖结果。所有这些事件都以不同的速度发生，并影响女性和男性的不同器官。问题是生殖衰老涉及哪些分子途径，以及衰老事件是否可能停止甚至逆转。所有这些问题的答案都将在本次审查中进行解释。