Obesity and its complications constitute a substantial burden. Considerable published research describes the novel relationships between obesity and gut microbiota communities. It is becoming evident that microbiota behave in a pivotal role in their ability to influence homeostatic mechanisms either to the benefit or detriment of host health, the extent of which is not fully understood. A greater understanding of the contribution of gut microbiota towards host pathophysiology is revealing new therapeutic avenues to tackle the global obesity epidemic. This review focuses on causal relationships and associations with obesity, proposed central mechanisms encouraging the development of obesity and promising prospective methods for microbiota manipulation.

中文翻译：

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肠道微生物群综述：肥胖病理生理学的核心因素

肥胖及其并发症构成了沉重的负担。大量已发表的研究描述了肥胖与肠道微生物群落之间的新关系。越来越明显的是，微生物群在其影响稳态机制的能力方面发挥着关键作用，无论是有益于还是有害于宿主健康，其程度尚不完全清楚。更深入地了解肠道微生物群对宿主病理生理学的贡献，揭示了应对全球肥胖流行的新治疗途径。本综述重点关注与肥胖的因果关系和关联，提出了促进肥胖发展的核心机制，以及有希望的微生物群操作方法。