Enteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on the mechanisms by which C. rodentium acquires nutrients as well as the distinct metabolic strategies that C. rodentium employs in varying spatiotemporal niches. We propose that identifying and targeting nutrients found essential for bacterial pathogenesis is an attractive anti-microbial approach in the new post-antibiotic era.

肠道细菌感染给社会带来了重大的全球健康负担，随着抗生素耐药性的增加，它们的威胁也在增加。因此，迫切需要快速开发新的抗微生物治疗方法，并且对靶向病原体营养和代谢的兴趣也在增长。在这篇综述中，我们重点介绍了最近关于啮齿类柠檬酸杆菌代谢的研究，这是一种小鼠特异性肠道致病性大肠杆菌(EPEC) 和肠出血性大肠杆菌(EHEC) 的亲戚。我们专注于通过该机制啮齿柠檬酸杆菌获得的营养以及独特的代谢策略，啮齿柠檬酸杆菌在不同的时空利基中使用。我们建议，在新的后抗生素时代，识别和靶向发现对细菌发病机制至关重要的营养素是一种有吸引力的抗微生物方法。