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Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy
Critical Reviews in Oncology/Hematology ( IF 6.2 ) Pub Date : 2021-07-07 , DOI: 10.1016/j.critrevonc.2021.103417
Jasmine Kaur 1 , Jackson Elms 1 , Alan L Munn 1 , David Good 2 , Ming Q Wei 1
Affiliation  

Non-small cell lung cancer (NSCLC) is of major concern for society as it is associated with high mortality and is one of the most commonly occurring of all cancers. Due to the number of mutational variants and general heterogeneity of this type of cancer, treatment using conventional modalities has been challenging. Therefore, it is important to have improved therapeutic treatments like immunotherapy, that can specifically treat the disease while causing minimal damage to healthy tissue and additionally provide systemic immunity. Cancer vaccines are an important element of cancer immunotherapy and have been approved for treatment of a limited number of cancers, including NSCLC. This article highlights scientific evidence for several therapeutic treatment strategies for NSCLC, alone or in combination, which offers new hope for those suffering. Although cancer vaccines have had some success as a monotherapy, their potential in a combination therapy needs to be critically analyzed for future applications.



中文翻译:

非小细胞肺癌 (NSCLC) 的免疫疗法,作为独立疗法和联合疗法

非小细胞肺癌 (NSCLC) 是社会的主要关注点,因为它与高死亡率有关,并且是所有癌症中最常见的癌症之一。由于此类癌症的突变变体数量和一般异质性,使用传统方式进行治疗一直具有挑战性。因此,重要的是有改进的治疗方法,如免疫疗法,它可以特异性地治疗疾病,同时对健康组织造成最小的损害,并额外提供全身免疫。癌症疫苗是癌症免疫疗法的重要组成部分,已被批准用于治疗有限数量的癌症,包括非小细胞肺癌。本文重点介绍了针对 NSCLC 的多种治疗策略的科学证据,单独或联合使用,为那些遭受痛苦的人提供了新的希望。

更新日期:2021-07-12
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