Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug-release activities,Polymer International

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Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug-release activities
Polymer International ( IF 2.9 ) Pub Date : 2021-07-07 , DOI: 10.1002/pi.6275
Zhangpeng Xu ₁ , Tuying Chen ₁ , Kai Meng ₁ , Huijing Zhao ₁

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Hydrogels are viable wound dressing materials that have gained increasing attention due to their specific physicochemical properties, biocompatibility and environmental responsiveness. In addition to keeping a wound area moist, hydrogels characterized by a porous network structure and regulated drug-release capacity promote the various phases of wound healing by effectively loading a drug and inducing anti-infection activity. In this study, we prepared a multifunctional hydrogel with antibacterial, hemostatic and sustained drug-release activities by chemically crosslinking silk fibroin (SF) and chitosan (CS) biomacromolecules. Results of characterization revealed that the synthesized hydrogel presents higher swelling and in vitro degradation rates under acidic conditions than in a neutral environment. Moreover, the three-dimensional network structure of the material and the transformation of the SF secondary structure resulted in enhanced compressive mechanical properties (maximum compressive stress of 50–130 kPa). In vitro studies of drug loading and release, antibacterial assay, cytotoxicity studies, and coagulation assay were performed. Results showed that the prepared hydrogel exhibits good bacteriostatic and hemostatic properties, and it is not toxic towards human skin fibroblasts. Therefore, the designed SF/CS hydrogel constitutes an excellent candidate material for wound dressings. © 2021 Society of Industrial Chemistry.

中文翻译：

具有抗菌、止血和缓释活性的丝素蛋白/壳聚糖水凝胶

水凝胶是一种可行的伤口敷料材料，由于其特定的物理化学特性、生物相容性和环境响应性而受到越来越多的关注。除了保持伤口区域湿润外，具有多孔网络结构和可控药物释放能力的水凝胶通过有效加载药物和诱导抗感染活性来促进伤口愈合的各个阶段。在这项研究中，我们通过化学交联丝素蛋白 (SF) 和壳聚糖 (CS) 生物大分子制备了一种具有抗菌、止血和持续药物释放活性的多功能水凝胶。表征结果表明，合成的水凝胶具有较高的溶胀性和体外酸性条件下的降解率高于中性环境。此外，材料的三维网络结构和 SF 二级结构的转变导致压缩力学性能增强（最大压缩应力为 50-130 kPa）。进行了药物装载和释放、抗菌试验、细胞毒性研究和凝血试验的体外研究。结果表明，制备的水凝胶具有良好的抑菌止血性能，对人体皮肤成纤维细胞无毒。因此，设计的 SF/CS 水凝胶构成了伤口敷料的极好候选材料。© 2021 工业化学学会。

更新日期：2021-07-07

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