Scale-down models (SDM) are crucial for efficient setting of different experimental conditions in cell culture media- or clone-screening applications and to predict the expected performance in larger bioreactor cultivations. However, the availability of such models for continuous bioprocessing are scarce and hampered by the requirement for proper cell retention in perfusion applications.

中文翻译：

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摇管灌注细胞培养是预测限制性底物、CSPR、出血策略、生长和生产力行为的合适工具

缩小模型 (SDM) 对于在细胞培养基或克隆筛选应用中有效设置不同实验条件以及预测大型生物反应器培养中的预期性能至关重要。然而，用于连续生物加工的此类模型的可用性很少，并且受到灌注应用中适当细胞保留的要求的阻碍。