Rubus coreanus Miquel (Bokbunja), a Korean black raspberry, is known to possess various phytochemicals exerting the effect on oxidation, inflammation, and cancer. However, most of studies have been performed with the solvent extracts and/or the single component to demonstrate the efficacy, and the study evaluating the effect of the whole fructus of Rubus coreanus Miquel is limited. In this study, therefore, we employed the isoproterenol (IPN)-induced myocardial infarction model and investigated the effect of freeze-dried powder of Rubus coreanus Miquel (RCP) on oxidative stress and protection of organ damage. Oral administration of RCP reduced the level of toxicity markers, alanine transaminase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) without affecting the body weight and diet intake. The oxidative stress marker glutathione (GSH) increased about 45% and malonaldehyde (MDA) decreased about 27% compared to the IPN group by RCP-H (3%) administration. In histological analysis, IPN induced significant myocardial damage in the heart and vascular injury in the liver, and RCP administration ameliorated the damages in a dose-dependent manner. Taken together, RCP activated the antioxidant system leading to the organ protection damaged by IPN in rats, making it possible to expect the beneficial efficacies by consuming the whole fructus of Rubus coreanus Miquel.

中文翻译：

---

Rubus coreanus Miquel 的冻干粉改善了异丙肾上腺素诱导的大鼠氧化应激和组织损伤。

Rubus coreanus Miquel ( Bokbunja ) 是一种韩国黑树莓，众所周知，它含有多种植物化学物质，可对氧化、炎症和癌症产生影响。然而，大多数研究都是用溶剂提取物和/或单一成分进行的，以证明其功效，而评估Rubus coreanus Miquel整个果实效果的研究是有限的。因此，在本研究中，我们采用了异丙肾上腺素 (IPN) 诱导的心肌梗死模型，并研究了悬钩子冻干粉的作用Miquel (RCP) 对氧化应激和保护器官损伤的作用。口服 RCP 可降低毒性标志物丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶 (AST) 和乳酸脱氢酶 (LDH) 的水平，而不会影响体重和饮食摄入。与 RCP-H (3%) 给药的 IPN 组相比，氧化应激标志物谷胱甘肽 (GSH) 增加了约 45%，丙二醛 (MDA) 减少了约 27%。在组织学分析中，IPN 在心脏和肝脏中引起显着的心肌损伤和血管损伤，而 RCP 给药以剂量依赖的方式改善损伤。总之，RCP 激活了抗氧化系统，导致大鼠因 IPN 受损的器官保护，使得通过食用整个果实可以预期有益的功效。悬钩子 coreanus Miquel。