Chlamydia pneumoniae is a type of pathogenic Gram-negative bacteria which causes various respiratory tract infections including asthma. Chlamydia species infect humans and cause respiratory infection by rupturing the lining of the respiratory tract such as the throat, lungs and windpipe. On the other hand, the function of Interleukin-4 (IL-4) in Ch. pneumoniae respiratory infection and its association with airway hyperresponsiveness (AHR) and development of adulthood and causing allergic airway disease (AAD) is not understood properly. Therefore, the present study aims to investigate the role of IL-4 in respiratory infection and allergy caused by early life Chlamydia infection. In this study, Ch. pneumonia strain was propagated and cultured in HEp-2 cells according to the standard protocol and infant C57BL/6 mice which is around 3-4 weeks were infected to study the role of IL-4 in respiratory infection and allergy caused by early life Chlamydia infection. The study observed that IL-4 is linked with Chlamydia respiratory infection and its absence lowers respiratory infection. IL-4R α2 is also responsible for controlling the IL-4 signaling pathway and averted the progression of infection and inflammation. Furthermore, the IL-4 signaling pathway also influences the infection-induced AHR and aids in increasing AAD severity. STAT6 also promotes respiratory infection caused by Ch. pneumoniae and further enhanced their downstream process. Therefore, the study concludes that IL-4 is a potential target for preventing infection-induced AHR and severity of asthma.

中文翻译：

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白介素 4 (IL-4) 在生命早期衣原体感染引起的呼吸道感染和过敏中的作用。

肺炎衣原体是一种致病性革兰氏阴性菌，可引起多种呼吸道感染，包括哮喘。衣原体感染人类并通过破坏呼吸道内壁（如喉咙、肺和气管）引起呼吸道感染。另一方面，白细胞介素 4 (IL-4) 在Ch 中的功能。肺炎支原体呼吸道感染及其与气道高反应性 (AHR) 和成年期发展以及引起过敏性气道疾病 (AAD) 的关系尚不明确。因此，本研究旨在探讨IL-4在生命早期衣原体感染引起的呼吸道感染和过敏中的作用。在这项研究中，Ch。肺炎按照标准方案在HEp-2细胞中增殖培养菌株，感染3-4周龄的幼年C57BL/6小鼠，研究IL-4在生命早期衣原体感染引起的呼吸道感染和过敏中的作用。该研究观察到 IL-4 与衣原体呼吸道感染有关，它的缺失会降低呼吸道感染。IL-4R α2 还负责控制 IL-4 信号通路并避免感染和炎症的进展。此外，IL-4 信号通路还影响感染诱导的 AHR 并有助于增加 AAD 的严重程度。STAT6 还促进由Ch.引起的呼吸道感染。肺炎球菌并进一步加强了他们的下游工艺。因此，该研究得出结论，IL-4 是预防感染引起的 AHR 和哮喘严重程度的潜在靶点。