The liver is an important immunological site that can promote immune tolerance or activation. Natural killer (NK) cells are a major immune subset within the liver, and therefore understanding their role in liver homeostasis and inflammation is crucial. Due to their cytotoxic function, NK cells are important in the immune response against hepatotropic viral infections but are also involved in the inflammatory processes of autoimmune liver diseases and fatty liver disease. Whether NK cells primarily promote pro-inflammatory or tolerogenic responses is not known for many liver diseases. Understanding the involvement of NK cells in liver inflammation will be crucial in effective treatment and future immunotherapeutic targeting of NK cells in these disease settings. Here, we explore the role that NK cells play in inflammation of the liver in the context of viral infection, autoimmunity and fatty liver disease.

肝脏是一个重要的免疫部位，可以促进免疫耐受或激活。自然杀伤 (NK) 细胞是肝脏内的主要免疫亚群，因此了解它们在肝脏稳态和炎症中的作用至关重要。由于其细胞毒性功能，NK 细胞在针对嗜肝病毒感染的免疫反应中很重要，但也参与自身免疫性肝病和脂肪肝的炎症过程。对于许多肝脏疾病，NK 细胞是否主要促进促炎或耐受性反应尚不清楚。了解 NK 细胞在肝脏炎症中的参与对于这些疾病环境中 NK 细胞的有效治疗和未来免疫治疗靶向至关重要。这里，