Preparation of carbon dots-based nanoparticles and their research of bioimaging and targeted antitumor therapy,Journal of Biomedical Materials Research Part B: Applied Biomaterials

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Preparation of carbon dots-based nanoparticles and their research of bioimaging and targeted antitumor therapy
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.2 ) Pub Date : 2021-07-07 , DOI: 10.1002/jbm.b.34905
Xuan Chen ₁ , Xiaoyu Sui ₂ , Shuting Lu ₁ , Yanmei Qu ₁ , Tingting Liu ₂ , Ting Wang ₁

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Carbon dots (CDs) are nanomaterials with excellent photoluminescence property, usually used in the field of bioimaging tumor cells. However, its practical applicability in cancer therapeutics is limited by CDs' insensitive surface properties to complicated tumor microenvironment in vivo. Herein, a new type of innovative biomimetic nanoparticles has been formed with HeLa cell membranes (CM) and multifunctional CDs containing antitumor and bioimaging activities. The CDs are prepared by a facile one-step microwave-assisted procedure. Gallic acid is used as carbon resource and antitumor active molecule. Gelatin is treated as the nitrogen resource. Citric acid monohydrate is used as the auxiliary carbon source and the Hela CM is used for tumor targeting. A series of fluorescence analyses has proved its homotypic targeting and ability of diagnosis. Besides, in vitro and in vivo antitumor experiments further indicate their better antitumor efficiency. The findings show the totally new nanoparticles' feasibilities of dealing with the clinical therapy problems as well as applying for the integration of diagnosis and targeting therapy.

中文翻译：

碳点纳米粒子的制备及其在生物成像和靶向抗肿瘤治疗方面的研究

碳点（CDs）是一种具有优异光致发光性能的纳米材料，通常用于肿瘤细胞的生物成像领域。然而，其在癌症治疗中的实际应用受到CDs对体内复杂肿瘤微环境不敏感的表面特性的限制。在此，一种新型的创新仿生纳米粒子已经形成，具有 HeLa 细胞膜 (CM) 和具有抗肿瘤和生物成像活性的多功能 CD。CD 是通过简单的一步微波辅助程序制备的。没食子酸用作碳资源和抗肿瘤活性分子。明胶被视为氮资源。柠檬酸一水合物用作辅助碳源，Hela CM 用于肿瘤靶向。一系列荧光分析证明了其同型靶向性和诊断能力。此外，体外和体内抗肿瘤实验进一步表明它们具有更好的抗肿瘤效果。研究结果显示了全新纳米粒子在解决临床治疗问题以及应用于诊断和靶向治疗一体化方面的可行性。

更新日期：2021-07-07

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