ABSTRACT Mathematical modelling and computer simulations are important tools in the field of cardiac electrophysiology. High computational costs of complex models make them difficult to apply in large-scale simulations like tissue. Therefore, model reduction are of particular importance in heart studies. In this paper, we introduce a technique for simplification of ventricular cell(VC) complex models. By using this technique, starting with a complex model of human VC including 17state variables, we reduce the number of state variables to two. Our simplified model is compared with the original one via several electrophysiological features and computational efficiency. Results show that the reduced model has acceptable behaviours in single cell and one-dimensional simulation, moreover, is 55 times faster than the original one. As the presented method does not depend on the reference model, it may be applied to every cardiac cell models or each complex excitable dynamical systems with the same dynamics as VC.

中文翻译：

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一种降低人心室动作电位模型的方法

摘要 数学建模和计算机模拟是心脏电生理学领域的重要工具。复杂模型的高计算成本使其难以应用于组织等大规模模拟。因此，模型简化在心脏研究中尤为重要。在本文中，我们介绍了一种简化心室细胞 (VC) 复杂模型的技术。通过使用这种技术，从包含 17 个状态变量的人类 VC 的复杂模型开始，我们将状态变量的数量减少到两个。我们的简化模型通过几个电生理特征和计算效率与原始模型进行了比较。结果表明，简化模型在单细胞和一维模拟中具有可接受的行为，而且比原始模型快 55 倍。