The mechanism of metabolic crosstalk between different tissues in the host remains poorly understood but is likely to play important roles in tumor growth and cachexia. A recent study from Naser, Jackstadt, et al. utilizes isotope tracing in a zebrafish melanoma model and finds that tumors secrete alanine into circulation, which is taken up by the liver and used for gluconeogenesis.

中文翻译：

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斑马鱼作为研究肿瘤与宿主代谢之间串扰的新模型

宿主不同组织之间代谢串扰的机制仍然知之甚少，但可能在肿瘤生长和恶病质中发挥重要作用。Naser、Jackstadt等人最近的一项研究。在斑马鱼黑色素瘤模型中利用同位素示踪，发现肿瘤分泌丙氨酸进入循环，被肝脏吸收并用于糖异生。