TRAP1, the mitochondrial component of the Hsp90 family of molecular chaperones, displays important bioenergetic and proteostatic functions. In tumor cells, TRAP1 contributes to shape metabolism, dynamically tuning it with the changing environmental conditions, and to shield from noxious insults. Hence, TRAP1 activity has profound effects on the capability of neoplastic cells to evolve towards more malignant phenotypes. Here, we discuss our knowledge on the biochemical functions of TRAP1 in the context of a growing tumor mass, and we analyze the possibility of targeting its chaperone functions for developing novel anti-neoplastic approaches.

中文翻译：

---

癌症中的分子伴侣 TRAP1：从生物学基础到药理学靶向

TRAP1 是 Hsp90 分子伴侣家族的线粒体成分，具有重要的生物能量和蛋白质稳定功能。在肿瘤细胞中，TRAP1 有助于塑造新陈代谢，随着环境条件的变化动态调整它，并保护免受有害伤害。因此，TRAP1 活性对肿瘤细胞向更恶性表型进化的能力具有深远的影响。在这里，我们讨论了我们在肿瘤块不断增长的背景下对 TRAP1 的生化功能的了解，并分析了靶向其伴侣功能以开发新的抗肿瘤方法的可能性。