Precise Encoding of Triple-Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging Application,Angewandte Chemie International Edition

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Precise Encoding of Triple-Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging Application
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-07-06 , DOI: 10.1002/anie.202106136
Wei Zhu ₁ , Er-Li Cai ₂ , Hao-Zheng Li ₂ , Ping Wang ₂ , Ai-Guo Shen _{1,

3} , Jürgen Popp _{4,

5} , Ji-Ming Hu _{1,

6}

Affiliation

Stimulated Raman scattering (SRS) microscopy in combination with innovative tagging strategies offers great potential as a universal high-throughput biomedical imaging tool. Here, we report rationally tailored small molecular monomers containing triple-bond units with large Raman scattering cross-sections, which can be polymerized at the nanoscale for enhancement of SRS contrast with smaller but brighter optical nanotags with artificial fingerprint output. From this, a class of triple-bond rich polymer nanoparticles (NPs) was engineered by regulating the relative dosages of three chemically different triple-bond monomers in co-polymerization. The bonding strategy allowed for 15 spectrally distinguishable triple-bond combinations. These accurately structured nano molecular aggregates, rather than long-chain macromolecules, could establish a universal method for generating small-sized biological SRS imaging tags with high sensitivity for high-throughput multi-color biomedical imaging.

中文翻译：

用于多重成像应用的单一聚合物纳米粒子三键拉曼散射的精确编码

受激拉曼散射 (SRS) 显微镜结合创新的标记策略提供了作为通用高通量生物医学成像工具的巨大潜力。在这里，我们报告了合理定制的小分子单体，其中包含具有大拉曼散射截面的三键单元，可以在纳米级聚合以增强 SRS 对比度，并具有更小但更亮的具有人工指纹输出的光学纳米标签。由此，通过调节共聚中三种化学性质不同的三键单体的相对剂量，设计了一类富含三键的聚合物纳米粒子 (NPs)。键合策略允许 15 种光谱可区分的三键组合。这些结构精确的纳米分子聚集体，而不是长链大分子，

更新日期：2021-07-06

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