ABSTRACT

Objectives

The aim of this study was to investigate the relationship between the C-reactive protein/albumin ratio and the prognosis of hypertensive COVID-19 patients.

Methods

It was designed as a single center retrospective study. PCR positive COVID-19 patients who were followed up in the intensive care unit (ICU) and received antihypertensive treatment were included in the study. The patients were divided into two groups as survivor and non-survivor. C-reactive protein/albumin (CAR) ratios of the patients were compared. The cut-off value was determined as a mortality predictor. The effect of CAR on mortality was evaluated using Logistic Regression analysis.

Results

281 patients were included in the study. Groups consisted of 135 (non-survivor) and 146 (survivor) patients. CAR was significantly higher in the non-survivor group (p<0.001). The area under the ROC curve for CAR for mortality was 0.807, with sensitivity of 0.71 and specificity of 0.71. The cut-off value for CAR was calculated as 56.62. In logistic regression analysis, CAR increases mortality 4.9 times compared to the cut-off value.

Conclusion

CAR is a powerful and independent prognostic marker for predicting mortality and disease progression in hypertensive COVID-19 patients.

中文翻译：

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C反应蛋白/白蛋白比值对高血压COVID-19患者的预后价值

摘要

目标

本研究的目的是调查 C 反应蛋白/白蛋白比率与高血压 COVID-19 患者预后之间的关系。

方法

它被设计为单中心回顾性研究。在重症监护病房 (ICU) 随访并接受抗高血压治疗的 PCR 阳性 COVID-19 患者被纳入研究。将患者分为幸存者和非幸存者两组。比较了患者的 C 反应蛋白/白蛋白 (CAR) 比率。临界值被确定为死亡率预测因子。使用逻辑回归分析评估 CAR 对死亡率的影响。

结果

281 名患者被纳入研究。组由 135 名（非幸存者）和 146 名（幸存者）患者组成。非幸存者组的 CAR 显着升高（p<0.001）。CAR 死亡率的 ROC 曲线下面积为 0.807，敏感性为 0.71，特异性为 0.71。CAR 的临界值计算为 56.62。在逻辑回归分析中，与临界值相比，CAR 使死亡率增加了 4.9 倍。

结论

CAR 是一种强大且独立的预后标志物，用于预测高血压 COVID-19 患者的死亡率和疾病进展。