Synthesis of Biaryl Phosphine Palladium(0) Precatalysts,Organometallics

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Synthesis of Biaryl Phosphine Palladium(0) Precatalysts
Organometallics ( IF 2.5 ) Pub Date : 2021-07-06 , DOI: 10.1021/acs.organomet.1c00288
Raphael Bigler ₁ , Daniel Spiess ₁ , Joël Wellauer ₁ , Martin Binder ₂ , Victor Carré ₁ , Serena Fantasia ₁

Affiliation

Well-defined palladium precatalysts have become increasingly important in cross-coupling chemistry. Despite the wide choice of complexes available today, palladium(0) compounds bearing Buchwald’s biaryl phosphines are still under-represented. We present here an efficient and facile synthesis of biaryl phosphine palladium(0) complexes supported by a divinyltetramethyldisiloxane (dvtms) ligand. Starting from commercially available [Pd(allyl)Cl]₂, a variety of [Pd(L)(dvtms)] complexes can be accessed in high yields under mild reaction conditions. Their catalytic activity was tested in Buchwald–Hartwig couplings and found to be very good for both (hetero)aryl bromides and chlorides.

中文翻译：

联芳基膦钯(0)预催化剂的合成

明确定义的钯预催化剂在交叉偶联化学中变得越来越重要。尽管当今有多种配合物可供选择，但带有 Buchwald 联芳基膦的钯 (0) 化合物的代表性仍然不足。我们在此介绍了一种由二乙烯基四甲基二硅氧烷 (dvtms) 配体支持的联芳基膦钯 (0) 配合物的高效、简便合成。从市售的 [Pd(allyl)Cl] _{2 开始}，可以在温和的反应条件下以高产率获得各种 [Pd(L)(dvtms)] 配合物。在 Buchwald-Hartwig 偶联中测试了它们的催化活性，发现对（杂）芳基溴化物和氯化物都非常好。

更新日期：2021-08-09

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